Immune cell-derived extracellular vesicles–new strategies in cancer immunotherapy

P Yang, Y Peng, Y Feng, Z Xu, P Feng, J Cao… - Frontiers in …, 2021 - frontiersin.org
Immune cell-derived extracellular vesicles (EVs) have increasingly become the focus of
research due to their unique characteristics and bioinspired applications. They are lipid …

Competing endogenous RNA networks as biomarkers in neurodegenerative diseases

L Moreno-García, T López-Royo, AC Calvo… - International journal of …, 2020 - mdpi.com
Protein aggregation is classically considered the main cause of neuronal death in
neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration …

M2 macrophage-derived extracellular vesicles facilitate CD8+ T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway

J Pu, Z Xu, J Nian, Q Fang, M Yang, Y Huang, W Li… - Cell death …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is a common malignancy. CD8+ T cell-mediated immune
response is critical for the inhibition of HCC progression. M2 macrophages participate in …

[HTML][HTML] Mesenchymal stem cell-derived exosomes regulate the polarization and inflammatory response of macrophages via miR-21-5p to promote repair after …

D Shen, Z He - Annals of translational medicine, 2021 - ncbi.nlm.nih.gov
Background Myocardial ischemia-reperfusion injury is a type of myocardial ischemia that
has a significant impact on patients' health. We aimed to explore the protective effect of …

[HTML][HTML] The biogenesis, biological functions, and applications of macrophage-derived exosomes

X Shan, C Zhang, C Mai, X Hu, N Cheng… - Frontiers in molecular …, 2021 - frontiersin.org
Macrophage-derived exosomes have been implicated on the modulation of inflammatory
processes. Recent studies have shown that macrophage-derived exosomes contribute to …

[HTML][HTML] LncRNAs and rheumatoid arthritis: from identifying mechanisms to clinical investigation

W Huang, X Li, C Huang, Y Tang, Q Zhou… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic chronic autoinflammatory disease, and the synovial
hyperplasia, pannus formation, articular cartilage damage and bone matrix destruction …

Extracellular vesicles in multiple sclerosis: role in the pathogenesis and potential usefulness as biomarkers and therapeutic tools

M D'Anca, C Fenoglio, FR Buccellato, C Visconte… - Cells, 2021 - mdpi.com
Although extracellular vesicles (EVs) were initially relegated to a waste disposal role,
nowadays, they have gained multiple fundamental functions working as messengers in …

[HTML][HTML] Exosomes containing miR-122-5p secreted by LPS-induced neutrophils regulate the apoptosis and permeability of brain microvascular endothelial cells by …

Q Li, A Nong, Z Huang, K He, Y Jia… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Objective: To explore the effect of exosomes containing miR-122-5p secreted by
lipopolysaccharide (LPS)-induced neutrophils on the apoptosis and permeability of brain …

[HTML][HTML] Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances

E Zhang, P Phan, Z Zhao - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Cellular nanovesicles which are referred to as cell-derived, nanosized lipid bilayer
structures, have emerged as a promising platform for regulating immune responses. Owing …

Exosomal non-coding RNAs: emerging therapeutic targets in atherosclerosis

M Alidadi, A Hjazi, I Ahmad, R Mahmoudi… - Biochemical …, 2023 - Elsevier
Atherosclerosis is an LDL-driven and inflammatory disorder of the sub-endothelial space.
Available data have proposed that various factors could affect atherosclerosis pathogenesis …