The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …

A complex relationship exists between alcohol-drinking behavior and stress. Alcohol has
anxiety-reducing properties and can relieve stress, while at the same time acting as a …

γ-Aminobutyric acidA (GABAA) receptors mediate most of the fast inhibitory
neurotransmission in the CNS. They represent a major site of action for clinically relevant …

The term “neurosteroid”(NS) was introduced by Baulieu in 1981 to name a steroid hormone,
dehydroepiandrosterone sulfate (DHEAS), that was found at high levels in the brain long …

Context Alcohol facilitates γ-aminobutyric acid (GABA) function, and GABA type A (GABA A)
receptor–facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular …

Finasteride is the first 5αreductase inhibitor that received clinical approval for the treatment
of human benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern hair …

This article reviews data on ethanol and neurosteroid interactions in the CNS. We discuss
how GABAergic neurosteroids, including 3α, 5α-TH PROG and 3α, 5α-TH DOC, produced in …

Aggressive behavior can serve important adaptive functions in social species. However, if it
exceeds the species-typical pattern, it may become maladaptive. Very high or escalated …

For almost three decades now, the GABAergic synapse has been the focus of intense study
for its putative role in mediating many of the behavioral consequences associated with acute …