The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …

Interest in strontium (Sr) has persisted over the last three decades due to its unique
mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast …

Severe injuries and diseases of bone tissue caused by congenital disorder, extrinsic trauma,
infection, and osteosarcoma resection face significant challenges for complete recovery. The …

Animal Models for the Study of Human Disease, Second Edition, provides needed
information on model sharing, animal alternatives, animal ethics and access to databanks of …

Evidence is presented which supports the conclusion that the hormetic dose–response
model is the most common and fundamental in the biological and biomedical sciences …

The paper provides an account of how the hormetic dose response has emerged in recent
years as a serious dose-response model in toxicology and risk assessment after decades of …

The antiosteoporotic treatment strontium ranelate (SrRan) was shown to increase bone
mass and strength by dissociating bone resorption and bone formation. To identify the …

Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity
and mortality worldwide. These diseases result from aberrant tissue remodeling leading to …

The bone remodelling process is closely related to bone health. Osteoblasts and osteoclasts
participate in the bone remodelling process under the regulation of various factors inside …

Osteolytic diseases, including rheumatoid arthritis, osteomyelitis, and periodontitis, are
usually associated with bacterial infections. However, the precise mechanisms by which …