Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …

Because of profound effects observed in carcinogenesis, prostaglandins (PGs),
prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer …

The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is
the commonest cancer in men in the UK. We present a comprehensive analysis of AR …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

The cyclooxygenase-2 (COX-2) enzyme is frequently overexpressed in epithelial
malignancies including those of the breast, prostate, lung, kidney, ovary, and liver and …

Highlights•PGE2 receptor subtypes EP1–4 are valuable drug targets.•Structural features for
subtype-selective activity of EP1–4 receptor modulators are presented.•Binding affinities …

The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by
signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse …

Cancer initiation and progression are multistep events that require cell proliferation,
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …

Prostaglandins are lipid compounds that mediate many physiological effects. Prostaglandin
E2 (PGE 2) is the most abundant prostanoid in the human body, and synthesis of PGE 2 is …

Purpose: Immunotherapies targeting immune checkpoint molecules have shown promising
treatment for a subset of cancers; however, many “cold” tumors, such as prostate cancer …