Multi-omics in spinal cord injury: Diagnosis, prognosis, and treatment

H Xu, W Zhao, Y Zhou, L Zhang - Cellular and Molecular Biology, 2022 - cellmolbiol.org
A spinal cord injury (SCI) can result in varying degrees of limb movement impairment and
sensory impairment, affecting the quality of life severely. The study of the molecular …

[HTML][HTML] Screening analysis of sirtuins family expression on anti-inflammation of resveratrol in endothelial cells

H Yu, W Pan, H Huang, J Chen, B Sun… - … medical journal of …, 2019 - ncbi.nlm.nih.gov
Background Resveratrol has been shown to possess beneficial activities including
antioxidant, anti-inflammatory, and cardioprotective effects through activating a nicotinamide …

[HTML][HTML] Mechanisms of PDGF siRNA-mediated inhibition of bone cancer pain in the spinal cord

Y Xu, J Liu, M He, R Liu, V Belegu, P Dai, W Liu… - Scientific reports, 2016 - nature.com
Patients with tumors that metastasize to bone frequently suffer from debilitating pain, and
effective therapies for treating bone cancer are lacking. This study employed a novel …

Endoplasmic reticulum protein 29 protects cortical neurons from apoptosis and promoting corticospinal tract regeneration to improve neural behavior via caspase and …

R Liu, W Zhao, Q Zhao, SJ Liu, J Liu, M He, Y Xu… - Molecular …, 2014 - Springer
Following spinal cord injury (SCI), limit spontaneous functional recovery often emerged.
However, the neuronal mechanisms associated with this phenomenon still remains obscure …

[HTML][HTML] RNA-Seq reveals miRNA role shifts in seven stages of skeletal muscles in goat fetuses and kids

Y Ling, Q Zheng, J Jing, M Sui, L Zhu, Y Li… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are indispensable for the regulation of skeletal muscle. We performed
RNA sequencing (RNA-seq) to establish a comprehensive miRNA profiling of goats in seven …

[HTML][HTML] Transcriptome alterations and therapeutic drugs in different organs after spinal cord injury based on integrated bioinformatic analysis

H Dong, D Shi, Y Bao, X Chen, L Zhou, H Lin… - Journal of …, 2023 - Elsevier
Objective To identify transcriptomic alterations and therapeutic drugs in different organs after
spinal cord injury via comprehensive bioinformatics analyses. Methods RNA-sequencing …

[HTML][HTML] miR-434-3p and DNA hypomethylation co-regulate eIF5A1 to increase AChRs and to improve plasticity in SCT rat skeletal muscle

FF Shang, QJ Xia, W Liu, L Xia, BJ Qian, L You… - Scientific Reports, 2016 - nature.com
Acetylcholine receptors (AChRs) serve as connections between motor neurons and skeletal
muscle and are essential for recovery from spinal cord transection (SCT). Recently …

[HTML][HTML] eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach

W Liu, FF Shang, Y Xu, V Belegu, L Xia, W Zhao… - Scientific reports, 2015 - nature.com
Spinal cord injury (SCI) is frequently accompanied by a degree of spontaneous functional
recovery. The underlying mechanisms through which such recovery is generated remain …

[HTML][HTML] MicroRNA339 targeting PDXK improves motor dysfunction and promotes neurite growth in the remote cortex subjected to spinal cord transection

LL Xiong, YX Qin, QX Xiao, Y Jin… - Frontiers in cell and …, 2020 - frontiersin.org
Spinal cord injury (SCI) is a fatal disease that can cause severe disability. Cortical
reorganization subserved the recovery of spontaneous function after SCI, although the …

Releasing of herpes simplex virus carrying NGF in subarachnoid space promotes the functional repair in spinal cord injured rats

ZW Chen, HP Wang, FM Yuan, X Zhang… - Current Gene …, 2016 - ingentaconnect.com
Background: Spinal cord injury (SCI) is a serious disease which can lead to bad
consequence in patients. Gene therapies, as an effective strategy, have been developed for …