The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …

Liver disease is a major global health-care problem, affecting an estimated 844 million
people worldwide. Despite this substantial burden, therapeutic options for liver disease …

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive
fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better …

Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …

During the onset of liver fibrosis, capillarized liver sinusoidal endothelial cells (LSECs) limit
substance exchange between the blood and the Disse space, further accelerating hepatic …

Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet
patient need. Recent use of single‐cell RNA sequencing (scRNAseq) has identified …

Macrophages are a heterogeneous population of innate immune cells and key cellular
components of the liver. Hepatic macrophages consist of embryologically-derived resident …

Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type
2 diabetes. The molecular mechanisms that mediate this response occur across many highly …

Organ fibrosis is a serious health challenge worldwide, and its global incidence and medical
burden are increasing dramatically each year. Fibrosis can occur in nearly all major organs …

Background: The exact focus of computed tomography (CT)-based artificial intelligence
techniques when staging liver fibrosis is still not exactly known. This study aimed to …