HSP70 and HSP90 are two powerful chaperone machineries involved in survival and
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …

During tumor development and progression, intrinsic and extrinsic factors trigger
endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the …

The discovery that endoplasmic reticulum (ER) luminal chaperones such as GRP78/BiP can
escape to the cell surface upon ER stress where they regulate cell signaling, proliferation …

Little is known about the composition and functional differences between extracellular
vesicle (EV) subsets, such as microvesicles (MVs) and exosomes (EXOs), nor to what extent …

Heat shock proteins (HSPs) constitute a large family of conserved proteins acting as
molecular chaperones that play a key role in intracellular protein homeostasis, regulation of …

The 94 kDa molecular chaperone, glucose‐regulated protein 94 (Grp94), has garnered
interest during the last decade due to its direct association with endoplasmic reticulum (ER) …

Stresses associated with disease may pathologically remodel the proteome by both
increasing interaction strength and altering interaction partners, resulting in proteome-wide …

Receptor‐mediated vesicular transport has been extensively developed to penetrate the
blood‐brain barrier (BBB) and has emerged as a class of powerful brain‐targeting delivery …

Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member
of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role …

The chaperome is a large and diverse protein machinery composed of chaperone proteins
and a variety of helpers, such as the co-chaperones, folding enzymes, and scaffolding and …