HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis
Z Albakova, Y Mangasarova, A Albakov… - Frontiers in …, 2022 - frontiersin.org
HSP70 and HSP90 are two powerful chaperone machineries involved in survival and
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …
Molecular chaperone GRP94/GP96 in cancers: oncogenesis and therapeutic target
X Duan, S Iwanowycz, S Ngoi, M Hill, Q Zhao… - Frontiers in …, 2021 - frontiersin.org
During tumor development and progression, intrinsic and extrinsic factors trigger
endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the …
endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the …
Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling
The discovery that endoplasmic reticulum (ER) luminal chaperones such as GRP78/BiP can
escape to the cell surface upon ER stress where they regulate cell signaling, proliferation …
escape to the cell surface upon ER stress where they regulate cell signaling, proliferation …
Characterisation of extracellular vesicle-subsets derived from brain endothelial cells and analysis of their protein cargo modulation after TNF exposure
V Dozio, JC Sanchez - Journal of extracellular vesicles, 2017 - Taylor & Francis
Little is known about the composition and functional differences between extracellular
vesicle (EV) subsets, such as microvesicles (MVs) and exosomes (EXOs), nor to what extent …
vesicle (EV) subsets, such as microvesicles (MVs) and exosomes (EXOs), nor to what extent …
Membrane-associated heat shock proteins in oncology: from basic research to new theranostic targets
Heat shock proteins (HSPs) constitute a large family of conserved proteins acting as
molecular chaperones that play a key role in intracellular protein homeostasis, regulation of …
molecular chaperones that play a key role in intracellular protein homeostasis, regulation of …
The biology and inhibition of glucose‐regulated protein 94/gp96
KW Pugh, M Alnaed, CM Brackett… - Medicinal research …, 2022 - Wiley Online Library
The 94 kDa molecular chaperone, glucose‐regulated protein 94 (Grp94), has garnered
interest during the last decade due to its direct association with endoplasmic reticulum (ER) …
interest during the last decade due to its direct association with endoplasmic reticulum (ER) …
Molecular stressors engender protein connectivity dysfunction through aberrant N-glycosylation of a chaperone
Stresses associated with disease may pathologically remodel the proteome by both
increasing interaction strength and altering interaction partners, resulting in proteome-wide …
increasing interaction strength and altering interaction partners, resulting in proteome-wide …
DH5α Outer Membrane‐Coated Biomimetic Nanocapsules Deliver Drugs to Brain Metastases but not Normal Brain Cells via Targeting GRP94
M Zhou, H Chen, Y Zeng, Z Lv, X Hu, Y Tong, P Wang… - Small, 2023 - Wiley Online Library
Receptor‐mediated vesicular transport has been extensively developed to penetrate the
blood‐brain barrier (BBB) and has emerged as a class of powerful brain‐targeting delivery …
blood‐brain barrier (BBB) and has emerged as a class of powerful brain‐targeting delivery …
Cell surface GRP94 as a novel emerging therapeutic target for monoclonal antibody cancer therapy
JW Kim, YB Cho, S Lee - Cells, 2021 - mdpi.com
Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member
of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role …
of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role …
Chemical tools to investigate mechanisms associated with HSP90 and HSP70 in disease
The chaperome is a large and diverse protein machinery composed of chaperone proteins
and a variety of helpers, such as the co-chaperones, folding enzymes, and scaffolding and …
and a variety of helpers, such as the co-chaperones, folding enzymes, and scaffolding and …