Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a
highly vascular microenvironment. These features are similar to those of tumour tissue, in …

Introduction Many genetic variants associated with common disease susceptibility occur
close to immune-related genes in noncoding DNA, suggestive of a regulatory function. The …

Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …

The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on" self" result in …

DNA-modifying enzymes participate in various genetic functions (eg, DNA replication,
repairing, and recombination) through alternating certain DNA sequence, and the …

Hodgkin lymphoma (HL), a B cell–derived cancer, is one of the most common lymphomas. In
HL, the tumor cells—Hodgkin and Reed-Sternberg (HRS) cells—are usually very rare in the …

Recent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-
risk subtype with an expression signature resembling that of Philadelphia chromosome …

Our understanding of familial predisposition to lymphoma (collectively defined as non-
Hodgkin lymphoma [NHL], Hodgkin lymphoma [HL], and chronic lymphocytic leukemia …

It is becoming increasingly clear that short and long noncoding RNAs critically participate in
the regulation of cell growth, differentiation, and (mis) function. However, while the functional …