Peering into avian influenza a (H5N8) for a framework towards pandemic preparedness

JY Yeo, SKE Gan - Viruses, 2021 - mdpi.com
2014 marked the first emergence of avian influenza A (H5N8) in Jeonbuk Province, South
Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak …

In Silico Protein Structure Analysis for SARS-CoV-2 Vaccines Using Deep Learning

Y Matsuzaka, R Yashiro - BioMedInformatics, 2023 - mdpi.com
Protein three-dimensional structural analysis using artificial intelligence is attracting
attention in various fields, such as the estimation of vaccine structure and stability. In …

Combined multiplexed phage display, high-throughput sequencing, and functional assays as a platform for identifying modulatory VHHs targeting the FSHR

A Zehnaker, A Vallet, J Gourdon, C Sarti… - International Journal of …, 2023 - mdpi.com
Developing modulatory antibodies against G protein-coupled receptors is challenging. In
this study, we targeted the follicle-stimulating hormone receptor (FSHR), a significant …

A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region

D Gialama, DM Vadukul, RJ Thrush… - Journal of Medicinal …, 2024 - ACS Publications
Increasing research efforts focus on exploiting antibodies to inhibit the amyloid formation of
neurodegenerative proteins. Nevertheless, it is challenging to discover antibodies that …

More than meets the kappa for antibody Superantigen protein L (PpL)

WL Ling, JY Yeo, YL Ng, A Wipat, SKE Gan - Antibodies, 2022 - mdpi.com
Immunoglobulin superantigens play an important role in affinity purification of antibodies
and the microbiota-immune axis at mucosal areas. Based on current understanding …

Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L

WL Ling, CTT Su, WH Lua, JY Yeo, JJ Poh, YL Ng… - Scientific Reports, 2022 - nature.com
Interest in IgA as an alternative antibody format has increased over the years with much
remaining to be investigated in relation to interactions with immune cells. Considering the …

Cell morphology as biomarker of carbapenem exposure

O Caliskan-Aydogan, C Zaborney Kline… - The Journal of …, 2024 - nature.com
Characterizing the physiological response of bacterial cells to antibiotics is crucial for
designing diagnostic techniques, treatment choices, and drug development. While bacterial …

Methods in bioinformatic and predictive virology

SKE Gan, EG Kostaki - Frontiers in Virology, 2023 - frontiersin.org
Viruses were cast under the international spotlight due to the global COVID-19 pandemic in
the early 2020s, renewing interests and applications in the field. With the pandemic still …

[HTML][HTML] The synergistic effects of the constant region and variable heavy chain families of multimeric immunoglobulin M on its interaction with Fc-mu receptor and …

WL Ling, SKE Gan - Exploration of Immunology, 2022 - explorationpub.com
Aim: As the primary response antibody with increasing use as a therapeutic immunoglobulin
(Ig) format, IgM is also the largest antibody structure among the five major human isotypes …

The synergistic effects of the VH families and CH regions of multimeric IgM on its interaction with FcμR, and antigen

WL Ling, SKE Gan - bioRxiv, 2022 - biorxiv.org
As the primary response antibody with increasing interest as a therapeutic antibody format,
IgM is also the largest antibody structure among the five major human isotypes …