Snake venoms are complex mixtures containing many different biologically active proteins
and peptides. A number of these proteins interact with components of the human hemostatic …

For more than half a century, cytotoxic agents have been investigated as a possible
treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues …

Mice with a targeted deletion of β3 integrin were used to examine the process by which
tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left …

The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper
venom, has been known for 2 decades, and their impact on cellular research has been …

The extracellular matrix (ECM) is an active and complex microenvironment with outstanding
biomechanical, biophysical, and biochemical characteristics, which can indirectly or directly …

Abstract Effects of ionising radiation on extracellular matrix (ECM)-modulated cell survival
and on adhesion and invasion are not well understood. In particular, the aggressiveness of …

Integrin ligands almost invariably employ a variant of either the RGD or LDV motif as a key
element of their receptor recognition site. These short acidic peptide sequences collaborate …

Targeting tumor-associated vascular endothelium by replication-competent viral vectors is a
promising strategy for cancer gene therapy. Here we describe the development of a viral …

Abstract Integrin-linked kinase (ILK), bound to the cytoplasmic tails of integrin β1, β2, and β3,
is thought to signal through AKT and glycogen synthase kinase-3β (GSK-3β) for survival and …

Species in the genus Echis have been classified mainly based on their morphological
appearance and the analytical patterns of their serum. However, re-classification of the …