HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
HIV-1 antiretroviral drug therapy
EJ Arts, DJ Hazuda - Cold Spring Harbor …, 2012 - perspectivesinmedicine.cshlp.org
The most significant advance in the medical management of HIV-1 infection has been the
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer
The HIV-1 envelope glycoprotein (Env) trimer contains the receptor binding sites and
membrane fusion machinery that introduce the viral genome into the host cell. As the only …
membrane fusion machinery that introduce the viral genome into the host cell. As the only …
Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody
JS McLellan, M Chen, S Leung, KW Graepel, X Du… - Science, 2013 - science.org
The prefusion state of respiratory syncytial virus (RSV) fusion (F) glycoprotein is the target of
most RSV-neutralizing activity in human sera, but its metastability has hindered …
most RSV-neutralizing activity in human sera, but its metastability has hindered …
Crystal structure of a soluble cleaved HIV-1 envelope trimer
HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env)
trimers that have been challenging to characterize structurally. Here, we describe the crystal …
trimers that have been challenging to characterize structurally. Here, we describe the crystal …
[HTML][HTML] Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of
great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated …
great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated …
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Abstract Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1)
gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are …
gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are …
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
During HIV-1 infection, antibodies are generated against the region of the viral gp120
envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these …
envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these …