Neural circuits, such as synaptic plasticity and neural activity, are critical components of
healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing …

GABA is the major inhibitory neurotransmitter in the mature CNS. When GABA A receptors
are activated the membrane potential is driven towards hyperpolarization due to chloride …

We developed a neural network model that can account for major elements common to
human focal seizures. These include the tonic-clonic transition, slow advance of clinical …

Understanding seizure formation and spread remains a critical goal of epilepsy research.
We used fast in vivo two-photon calcium imaging in male mouse neocortex to reconstruct …

Seizures are characterized by hypersynchronization of neuronal networks. Understanding
these networks could provide a critical window for therapeutic control of recurrent seizure …

To better understand the input-output computations of neuronal populations, we developed
ArcLight-ST, a genetically-encoded voltage indicator, to specifically measure subthreshold …

During human seizures, organized waves of voltage activity rapidly sweep across the cortex.
Two contradictory theories describe the source of these fast traveling waves: either a slowly …

The mitochondrial calcium (Ca2+) uniporter (MCU) mediates high-capacity mitochondrial
Ca2+ uptake implicated in ischemic/reperfusion cell death. We have recently shown that …

Spreading depression (SD) is an intense and prolonged depolarization in the central
nervous systems from insect to man. It is implicated in neurological disorders such as …

Focal epilepsy involves excessive cortical activity that propagates both locally and distally.
Does this propagation follow the same routes as normal cortical activity? We …