Flaviviral NS4b, chameleon and jack‐in‐the‐box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention
Dengue virus and other flaviviruses such as the yellow fever, West Nile, and Japanese
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …
Interplay between dengue virus and Toll-like receptors, RIG-I/MDA5 and microRNAs: Implications for pathogenesis
S Urcuqui-Inchima, J Cabrera, AL Haenni - Antiviral Research, 2017 - Elsevier
A growing body of evidence has demonstrated the role of components of innate immunity,
including Toll-like receptors (TLRs), the retinoic acid-inducible gene I/melanoma …
including Toll-like receptors (TLRs), the retinoic acid-inducible gene I/melanoma …
Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor
ABSTRACT RNA interference (RNAi) is an important antiviral defense response in plants
and invertebrates; however, evidences for its contribution to mammalian antiviral defense …
and invertebrates; however, evidences for its contribution to mammalian antiviral defense …
[HTML][HTML] P-body components LSM1, GW182, DDX3, DDX6 and XRN1 are recruited to WNV replication sites and positively regulate viral replication
HS Chahar, S Chen, N Manjunath - Virology, 2013 - Elsevier
In mammalian cells, proteins involved in mRNA silencing and degradation localize to
discrete cytoplasmic foci called processing or P-bodies. Here we show that microscopically …
discrete cytoplasmic foci called processing or P-bodies. Here we show that microscopically …
DDX3X helicase inhibitors as a new strategy to fight the West Nile virus infection
A Brai, F Martelli, V Riva, A Garbelli… - Journal of medicinal …, 2019 - ACS Publications
Increased frequency of arbovirus outbreaks in the last 10 years represents an important
emergence for global health. Climate warming, extensive urbanization of tropical regions …
emergence for global health. Climate warming, extensive urbanization of tropical regions …
Immune priming with inactive dengue virus during the larval stage of Aedes aegypti protects against the infection in adult mosquitoes
V Vargas, J Cime-Castillo, H Lanz-Mendoza - Scientific reports, 2020 - nature.com
Several studies have observed that the immune response in insects can be conserved, a
phenomenon known as immune priming, which has been mostly tested in adult stages …
phenomenon known as immune priming, which has been mostly tested in adult stages …
Antiviral responses of arthropod vectors: an update on recent advances
C Rückert, L Bell-Sakyi, JK Fazakerley, R Fragkoudis - Virusdisease, 2014 - Springer
Arthropod vectors, such as mosquitoes, ticks, biting midges and sand flies, transmit many
viruses that can cause outbreaks of disease in humans and animals around the world …
viruses that can cause outbreaks of disease in humans and animals around the world …
Systems biology reveals NS4B-cyclophilin A interaction: a new target to inhibit YFV replication
A Vidotto, ATS Morais, MR Ribeiro… - Journal of Proteome …, 2017 - ACS Publications
Yellow fever virus (YFV) replication is highly dependent on host cell factors. YFV NS4B is
reported to be involved in viral replication and immune evasion. Here interactions between …
reported to be involved in viral replication and immune evasion. Here interactions between …
[HTML][HTML] Argonaute 2 is up-regulated in tissues of urothelial carcinoma of bladder
Abstract Argonaute 2 proteins (Ago2) have been demonstrated to be widely expressed and
involved in post-transcriptional gene silencing and play key roles in carcinogenesis …
involved in post-transcriptional gene silencing and play key roles in carcinogenesis …
[HTML][HTML] Evaluation of Argonaute protein as a predictive marker for human clear cell renal cell carcinoma
Argonaute subfamily proteins are involved in human organ growth and development.
Recent studies found its association with human breast cancer, however, its expression …
Recent studies found its association with human breast cancer, however, its expression …