Flaviviral NS4b, chameleon and jack‐in‐the‐box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention

J Zmurko, J Neyts, K Dallmeier - Reviews in medical virology, 2015 - Wiley Online Library
Dengue virus and other flaviviruses such as the yellow fever, West Nile, and Japanese
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …

Interplay between dengue virus and Toll-like receptors, RIG-I/MDA5 and microRNAs: Implications for pathogenesis

S Urcuqui-Inchima, J Cabrera, AL Haenni - Antiviral Research, 2017 - Elsevier
A growing body of evidence has demonstrated the role of components of innate immunity,
including Toll-like receptors (TLRs), the retinoic acid-inducible gene I/melanoma …

Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor

PK Kakumani, SS Ponia, V Sood… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT RNA interference (RNAi) is an important antiviral defense response in plants
and invertebrates; however, evidences for its contribution to mammalian antiviral defense …

[HTML][HTML] P-body components LSM1, GW182, DDX3, DDX6 and XRN1 are recruited to WNV replication sites and positively regulate viral replication

HS Chahar, S Chen, N Manjunath - Virology, 2013 - Elsevier
In mammalian cells, proteins involved in mRNA silencing and degradation localize to
discrete cytoplasmic foci called processing or P-bodies. Here we show that microscopically …

DDX3X helicase inhibitors as a new strategy to fight the West Nile virus infection

A Brai, F Martelli, V Riva, A Garbelli… - Journal of medicinal …, 2019 - ACS Publications
Increased frequency of arbovirus outbreaks in the last 10 years represents an important
emergence for global health. Climate warming, extensive urbanization of tropical regions …

Immune priming with inactive dengue virus during the larval stage of Aedes aegypti protects against the infection in adult mosquitoes

V Vargas, J Cime-Castillo, H Lanz-Mendoza - Scientific reports, 2020 - nature.com
Several studies have observed that the immune response in insects can be conserved, a
phenomenon known as immune priming, which has been mostly tested in adult stages …

Antiviral responses of arthropod vectors: an update on recent advances

C Rückert, L Bell-Sakyi, JK Fazakerley, R Fragkoudis - Virusdisease, 2014 - Springer
Arthropod vectors, such as mosquitoes, ticks, biting midges and sand flies, transmit many
viruses that can cause outbreaks of disease in humans and animals around the world …

Systems biology reveals NS4B-cyclophilin A interaction: a new target to inhibit YFV replication

A Vidotto, ATS Morais, MR Ribeiro… - Journal of Proteome …, 2017 - ACS Publications
Yellow fever virus (YFV) replication is highly dependent on host cell factors. YFV NS4B is
reported to be involved in viral replication and immune evasion. Here interactions between …

[HTML][HTML] Argonaute 2 is up-regulated in tissues of urothelial carcinoma of bladder

FQ Yang, JH Huang, M Liu, FP Yang, W Li… - … journal of clinical and …, 2014 - ncbi.nlm.nih.gov
Abstract Argonaute 2 proteins (Ago2) have been demonstrated to be widely expressed and
involved in post-transcriptional gene silencing and play key roles in carcinogenesis …

[HTML][HTML] Evaluation of Argonaute protein as a predictive marker for human clear cell renal cell carcinoma

W Li, M Liu, Y Feng, YF Xu, JP Che… - … journal of clinical and …, 2013 - ncbi.nlm.nih.gov
Argonaute subfamily proteins are involved in human organ growth and development.
Recent studies found its association with human breast cancer, however, its expression …