Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

Colorectal cancer is a heterogeneous disease that develops via stepwise accumulation of
well-characterized genetic and epigenetic alterations. We review the genetic changes …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)
pathway is frequently mutated in human cancer. This pathway consists of a small GTP …

The progress in our understanding of early events in the development of colonic neoplasia
is the result of 2 advances:(1) improved characterization of lesions detected at endoscopy …

Objective Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal
carcinomas, but their biology is incompletely understood. We performed a …