Monitoring synaptic pathology in Alzheimer's disease through fluid and PET imaging biomarkers: a comprehensive review and future perspectives

S Lista, A Santos-Lozano, E Emanuele… - Molecular …, 2024 - nature.com
Alzheimer's disease (AD) is currently constrained by limited clinical treatment options. The
initial pathophysiological event, which can be traced back to decades before the clinical …

Alpha-synuclein in peripheral tissues as a possible marker for neurological diseases and other medical conditions

FJ Jiménez-Jiménez, H Alonso-Navarro… - Biomolecules, 2023 - mdpi.com
The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues
(blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological …

Co-aggregation of α-synuclein with amyloid-β stabilizes β-sheet-rich oligomers and enhances the formation of β-barrels

F Huang, Y Liu, Y Wang, J Xu, J Lian, Y Zou… - Physical Chemistry …, 2023 - pubs.rsc.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative diseases with markedly different pathological features of β-amyloid (Aβ) …

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients

L de Boni, A Wallis, A Hays Watson… - EMBO Molecular …, 2024 - embopress.org
Synucleinopathies such as Parkinson's disease (PD) are defined by the accumulation and
aggregation of the α-synuclein protein in neurons, glia and other tissues. We have …

Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes

V Cela, E Malacarne, MER Obino, I Marzi, F Papini… - Biomedicines, 2021 - mdpi.com
Endometriosis (EMS) pathogenesis has been related to the release of inflammatory
mediators in peritoneal fluid, creating an altered microenvironment that leads to low-grade …

α-synuclein as an emerging pathophysiological biomarker of Alzheimer's disease

MF Beatino, C De Luca, N Campese… - Expert Review of …, 2022 - Taylor & Francis
Introduction α-syn aggregates represent the pathological hallmark of synucleinopathies as
well as a frequent copathology (almost 1/3 of cases) in AD. Recent research indicates a …

Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

S Yadav, Deepika, K Moar, A Kumar, N Khola… - Biology of the …, 2024 - Wiley Online Library
Abstract Background Red blood cells (RBCs) are usually considered simple cells and
transporters of gases to tissues. Hypothesis However, recent research has suggested that …

LC–MS/MS assay for the investigation of acetylated Alpha-synuclein in serum from postmortem Alzheimer's disease pathology

K Uchida, K Morikawa, Y Muguruma… - … of Chromatography B, 2021 - Elsevier
Abstract Alpha-synuclein (α-Syn), a neuronal protein, has been linked to the inflammation
and development of neurodegenerative diseases. In a number of neurodegenerations, α …