Regulating specificity in enhancer–promoter communication
CC Galouzis, EEM Furlong - Current Opinion in Cell Biology, 2022 - Elsevier
Enhancers are cis-regulatory elements that can activate transcription remotely to regulate a
specific pattern of a gene's expression. Genes typically have many enhancers that are often …
specific pattern of a gene's expression. Genes typically have many enhancers that are often …
[HTML][HTML] Functions of HP1 proteins in transcriptional regulation
JM Schoelz, NC Riddle - Epigenetics & Chromatin, 2022 - Springer
In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to
transcription. Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) …
transcription. Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) …
Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains
SV Ulianov, EE Khrameeva, AA Gavrilov… - Genome …, 2016 - genome.cshlp.org
Recent advances enabled by the Hi-C technique have unraveled many principles of
chromosomal folding that were subsequently linked to disease and gene regulation. In …
chromosomal folding that were subsequently linked to disease and gene regulation. In …
[HTML][HTML] A Comprehensive Map of Insulator Elements for the Drosophila Genome
Insulators are DNA sequences that control the interactions among genomic regulatory
elements and act as chromatin boundaries. A thorough understanding of their location and …
elements and act as chromatin boundaries. A thorough understanding of their location and …
Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture
Eukaryotic gene expression is regulated by enhancer–promoter interactions but the
molecular mechanisms that govern specificity have remained elusive. Genome-wide studies …
molecular mechanisms that govern specificity have remained elusive. Genome-wide studies …
[HTML][HTML] Chromatin landscape dictates HSF binding to target DNA elements
MJ Guertin, JT Lis - PLoS genetics, 2010 - journals.plos.org
Sequence-specific transcription factors (TFs) are critical for specifying patterns and levels of
gene expression, but target DNA elements are not sufficient to specify TF binding in vivo. In …
gene expression, but target DNA elements are not sufficient to specify TF binding in vivo. In …
[HTML][HTML] Transcriptional silencers in Drosophila serve a dual role as transcriptional enhancers in alternate cellular contexts
A major challenge in biology is to understand how complex gene expression patterns are
encoded in the genome. While transcriptional enhancers have been studied extensively, few …
encoded in the genome. While transcriptional enhancers have been studied extensively, few …
[HTML][HTML] Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome
H Chen, Y Tian, W Shu, X Bo, S Wang - PloS one, 2012 - journals.plos.org
Chromatin insulators are DNA elements that regulate the level of gene expression either by
preventing gene silencing through the maintenance of heterochromatin boundaries or by …
preventing gene silencing through the maintenance of heterochromatin boundaries or by …
Insulators and promoters: closer than we think
JR Raab, RT Kamakaka - Nature Reviews Genetics, 2010 - nature.com
Insulators prevent promiscuous gene regulation by restricting the action of enhancers and
silencers. Recent studies have revealed a number of similarities between insulators and …
silencers. Recent studies have revealed a number of similarities between insulators and …
Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin
O Maksimenko, M Bartkuhn, V Stakhov… - Genome …, 2015 - genome.cshlp.org
Insulators are multiprotein–DNA complexes that regulate the nuclear architecture. The
Drosophila CP190 protein is a cofactor for the DNA-binding insulator proteins Su (Hw) …
Drosophila CP190 protein is a cofactor for the DNA-binding insulator proteins Su (Hw) …