Osteocytes in bone aging: Advances, challenges, and future perspectives
Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …
response to hormones and mechanical loading. Substantial evidence have demonstrated …
Aging, osteocytes, and mechanotransduction
Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …
Osteon: structure, turnover, and regeneration
Bone is composed of dense and solid cortical bone and honeycomb-like trabecular bone.
Although cortical bone provides the majority of mechanical strength for a bone, there are few …
Although cortical bone provides the majority of mechanical strength for a bone, there are few …
The role of osteocytes in age-related bone loss
RL Jilka, CA O'Brien - Current osteoporosis reports, 2016 - Springer
The decrease in bone mass and strength during aging has multiple causes. Osteocytes are
long-lived cells within the bone matrix that perform a variety of functions, including the …
long-lived cells within the bone matrix that perform a variety of functions, including the …
Similarities between disuse and age‐induced bone loss
EG Buettmann, GM Goldscheitter… - Journal of Bone and …, 2022 - Wiley Online Library
Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …
Changes in the osteocyte lacunocanalicular network with aging
LAM Tiede-Lewis, SL Dallas - Bone, 2019 - Elsevier
Osteoporosis is an aging-related disease of reduced bone mass that is particularly prevalent
in post-menopausal women, but also affects the aged male population and is associated …
in post-menopausal women, but also affects the aged male population and is associated …
The synergy of synchrotron imaging and convolutional neural networks towards the detection of human micro-scale bone architecture and damage
The growing health and economic burden of bone fractures, their intricate multiscale
features and the existing knowledge gaps in the comprehension of micro-scale bone …
features and the existing knowledge gaps in the comprehension of micro-scale bone …
[HTML][HTML] Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing
While advanced imaging strategies have improved the diagnosis of bone-related
pathologies, early signs of bone alterations remain difficult to detect. The Covid-19 …
pathologies, early signs of bone alterations remain difficult to detect. The Covid-19 …
Micro-and nano-CT for the study of bone ultrastructure
Micro-computed tomography (micro-CT)—a version of X-ray CT operating at high spatial
resolution—has had a considerable success for the investigation of trabecular bone micro …
resolution—has had a considerable success for the investigation of trabecular bone micro …
Network architecture strongly influences the fluid flow pattern through the lacunocanalicular network in human osteons
A popular hypothesis explains the mechanosensitivity of bone due to osteocytes sensing the
load-induced flow of interstitial fluid squeezed through the lacunocanalicular network (LCN) …
load-induced flow of interstitial fluid squeezed through the lacunocanalicular network (LCN) …