The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Lung cancer remains the leading cause of cancer-related deaths despite recent
breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has …

Metastasis is a major clinical obstacle responsible for the high mortality and poor prognosis
of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators of metastasis that act by …

Epithelial-to-mesenchymal transition (EMT) is a key process that occurs during tumor
metastasis, affecting a variety of malignancies including colorectal cancer (CRC). Exosomes …

There is a growing interest to understand the role and mechanism of action of microRNAs
(miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that …

Unlike most epithelial malignancies which metastasize hematogenously, metastasis of
epithelial ovarian cancer (EOC) occurs primarily via transcoelomic dissemination …

It is now widely accepted that several gene alterations including transcription factors are
critically involved in cancer progression and metastasis. Forkhead Box Class O proteins …

Abstract Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number
of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via …

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that
confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 …