Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Although altered glycosylation has been detected in human cancer cells decades ago, only
investigations in the last years have enormously increased our knowledge about the details …

CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially
identified as a receptor for hyaluronan that participates in both physiological and …

Cardiovascular diseases (CVDs) such as atherosclerosis, myocardial remodeling,
myocardial ischemia-reperfusion (I/R) injury, heart failure, and oxidative stress are among …

The circulating tumor cells (CTCs, the root cause of cancer metastasis and poor cancer
prognosis) are very difficult to culture for scale-up in vitro, which has hampered their use in …

Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

The development of delivery systems capable of tumor targeting represents a promising
strategy to overcome issues related to nonspecific effects of conventional anticancer …

Lipid microdomains, ordered membrane phases containing cholesterol and
glycosphingolipids, play an essential role in cancer cell adhesion and ultimately metastasis …

Metastasis is considered to be responsible for 90% of cancer-related deaths. Although it is
clinically evident that metastatic patterns vary by primary tumor type, the molecular …