The emerging nature of astrocyte diversity
BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …
homogeneous population tiling the entire central nervous system (CNS). However, this view …
Making sense of astrocytic calcium signals—from acquisition to interpretation
A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not
been quantified during natural sleep. Here, we employ an activity-based algorithm to assess …
been quantified during natural sleep. Here, we employ an activity-based algorithm to assess …
Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior
Astrocytes tile the central nervous system, but their functions in neural microcircuits in vivo
and their roles in mammalian behavior remain incompletely defined. We used two-photon …
and their roles in mammalian behavior remain incompletely defined. We used two-photon …
Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
L Hösli, N Binini, KD Ferrari, L Thieren, ZJ Looser… - Cell reports, 2022 - cell.com
The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …
Hippocampal astrocytes encode reward location
Astrocytic calcium dynamics has been implicated in the encoding of sensory information,,,–,
and modulation of calcium in astrocytes has been shown to affect behaviour,,,–. However …
and modulation of calcium in astrocytes has been shown to affect behaviour,,,–. However …
Cortical circuit activity evokes rapid astrocyte calcium signals on a similar timescale to neurons
Sensory stimulation evokes intracellular calcium signals in astrocytes; however, the timing of
these signals is disputed. Here, we used novel combinations of genetically encoded calcium …
these signals is disputed. Here, we used novel combinations of genetically encoded calcium …
Ion channels and electrophysiological properties of astrocytes: implications for emergent stimulation technologies
Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …
Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence
K Zhang, R Förster, W He, X Liao, J Li, C Yang… - Nature …, 2021 - nature.com
Memory persistence is a fundamental cognitive process for guiding behaviors and is
considered to rely mostly on neuronal and synaptic plasticity. Whether and how astrocytes …
considered to rely mostly on neuronal and synaptic plasticity. Whether and how astrocytes …
Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex
YJ Liu, EE Spangenberg, B Tang… - Journal of …, 2021 - Soc Neuroscience
Microglia have crucial roles in sculpting synapses and maintaining neural circuits during
development. To test the hypothesis that microglia continue to regulate neural circuit …
development. To test the hypothesis that microglia continue to regulate neural circuit …