The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep

L Bojarskaite, DM Bjørnstad, KH Pettersen… - Nature …, 2020 - nature.com
Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not
been quantified during natural sleep. Here, we employ an activity-based algorithm to assess …

Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior

X Yu, AMW Taylor, J Nagai, P Golshani, CJ Evans… - Neuron, 2018 - cell.com
Astrocytes tile the central nervous system, but their functions in neural microcircuits in vivo
and their roles in mammalian behavior remain incompletely defined. We used two-photon …

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

L Hösli, N Binini, KD Ferrari, L Thieren, ZJ Looser… - Cell reports, 2022 - cell.com
The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …

Hippocampal astrocytes encode reward location

A Doron, A Rubin, A Benmelech-Chovav, N Benaim… - Nature, 2022 - nature.com
Astrocytic calcium dynamics has been implicated in the encoding of sensory information,,,–,
and modulation of calcium in astrocytes has been shown to affect behaviour,,,–. However …

Cortical circuit activity evokes rapid astrocyte calcium signals on a similar timescale to neurons

JL Stobart, KD Ferrari, MJP Barrett, C Glück, MJ Stobart… - Neuron, 2018 - cell.com
Sensory stimulation evokes intracellular calcium signals in astrocytes; however, the timing of
these signals is disputed. Here, we used novel combinations of genetically encoded calcium …

Ion channels and electrophysiological properties of astrocytes: implications for emergent stimulation technologies

J McNeill, C Rudyk, ME Hildebrand… - Frontiers in Cellular …, 2021 - frontiersin.org
Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …

Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence

K Zhang, R Förster, W He, X Liao, J Li, C Yang… - Nature …, 2021 - nature.com
Memory persistence is a fundamental cognitive process for guiding behaviors and is
considered to rely mostly on neuronal and synaptic plasticity. Whether and how astrocytes …

Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex

YJ Liu, EE Spangenberg, B Tang… - Journal of …, 2021 - Soc Neuroscience
Microglia have crucial roles in sculpting synapses and maintaining neural circuits during
development. To test the hypothesis that microglia continue to regulate neural circuit …