The contact activation system (CAS) and kallikrein/kinin system (KKS) are older recognized
biochemical pathways that include several proteins that skirt the fringes of the blood …

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results
in the release of vasoactive kinins (bradykinin-related peptides). This complex system …

Background Mutations and epigenetic aberrant signaling of growth factors pathways
contribute to carcinogenesis. Recent studies reveal that non-coding RNAs are controllers of …

Hereditary angioedema (HAE), characterized by recurrent episodes of angioedema
involving the skin, or the mucosa of the upper respiratory or the gastrointestinal tracts, results …

Background Attacks of hereditary angioedema (HAE) are unpredictable and, if affecting the
upper airway, can be lethal. Icatibant is used for physician-or patient self-administered …

OBJECTIVE: To review the mechanisms by which bradykinin is generated in hereditary
angioedema (HAE)(C1 inhibitor deficiency), including the role of human plasma proteins …

The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …

Investigations were performed to define the factor XII (FXII) binding site (s) on cultured
endothelial cells (HUVECs). Biotin-or fluorescein isothiocyanate (FITC)–FXII in the presence …

There is mounting evidence that zinc, the second most abundant transition metal in blood, is
an important mediator of haemostasis and thrombosis. Prompted by the observation that …

Assembly and activation of the plasma KKS on endothelial cells. Plasma PK circulates in
complex with HK. The HK• PK complex binds to a multiprotein receptor complex that consists …