Brain glucose metabolism: integration of energetics with function

GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Molecular pathophysiology of hepatic glucose production

K Sharabi, CDJ Tavares, AK Rines… - Molecular aspects of …, 2015 - Elsevier
Maintaining blood glucose concentration within a relatively narrow range through periods of
fasting or excess nutrient availability is essential to the survival of the organism. This is …

First results on kinetic modelling and parametric imaging of dynamic 18F-FDG datasets from a long axial FOV PET scanner in oncological patients

H Sari, C Mingels, I Alberts, J Hu, D Buesser… - European journal of …, 2022 - Springer
Purpose To investigate the kinetics of 18 F-fluorodeoxyglucose (18 F-FDG) by positron
emission tomography (PET) in multiple organs and test the feasibility of total-body …

Pathogenesis of type 2 diabetes mellitus

RA DeFronzo - Medical clinics, 2004 - medical.theclinics.com
A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

RA DeFronzo, R Gunnarsson… - The Journal of …, 1985 - Am Soc Clin Investig
The mechanism (s) and site (s) of the insulin resistance were examined in nine normal-
weight noninsulin-dependent diabetic (NIDD) subjects. The euglycemic insulin clamp …

Positron emission tomography study of human brain functional development

HT Chugani, ME Phelps, JC Mazziotta - Annals of neurology, 1987 - Wiley Online Library
From over 100 children studied with 2‐deoxy‐2 {18F} fluoro‐d‐glucose and positron
emission tomography we selected 29 children (aged 5 days to 15.1 years) who had suffered …

Positron emission tomography provides molecular imaging of biological processes

ME Phelps - Proceedings of the National Academy of …, 2000 - National Acad Sciences
Diseases are biological processes, and molecular imaging with positron emission
tomography (PET) is sensitive to and informative of these processes. This is illustrated by …

An overview of CEST MRI for non-MR physicists

B Wu, G Warnock, M Zaiss, C Lin, M Chen, Z Zhou… - EJNMMI physics, 2016 - Springer
The search for novel image contrasts has been a major driving force in the magnetic
resonance (MR) research community, in order to gain further information on the body's …

Reduction of prefrontal cortex glucose metabolism common to three types of depression

LR Baxter, JM Schwartz, ME Phelps… - Archives of general …, 1989 - jamanetwork.com
• Using positron emission tomography, we studied cerebral glucose metabolism in drug-free,
age-and sex-matched, righthanded patients with unipolar depression (n= 10), bipolar …

Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder

LR Baxter, JM Schwartz, KS Bergman… - Archives of general …, 1992 - jamanetwork.com
• We used positron emission tomography to investigate local cerebral metabolic rates for
glucose (LCMRG1c) in patients with obsessive-compulsive disorder before and after …