Cryo-EM reveals an unprecedented binding site for NaV1. 7 inhibitors enabling rational design of potent hybrid inhibitors

M Kschonsak, CC Jao, CP Arthur, AL Rohou… - Elife, 2023 - elifesciences.org
The voltage-gated sodium (Na V) channel Na V 1.7 has been identified as a potential novel
analgesic target due to its involvement in human pain syndromes. However, clinically …