The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-
end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable …

Selection of the translational initiation site in most eukaryotic mRNAs appears to occur via a
scanning mechanism which predicts that proximity to the 5′ end plays a dominant role in …

Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …

EUKARYOTIC cellular mRNAs have a 5'cap structure (m7 GpppX) that facilitates binding to
ribosomes and is required for efficient translation1–3. A specific initiation factor, eIF-4F …

The contribution of the mRNA cap-binding protein, eIF-4E, to malignant transformation and
progression has been illuminated over the past decade. eIF-4E overexpression has been …

Using a sensitive transfection-tumorigenicity assay, we have isolated a novel transforming
gene from the DNA of two patients with chronic myelogenous leukemia. Sequence analysis …

Five structural features in mRNAs have been found to contribute to the fidelity and efficiency
of initiation by eukaryotic ribosomes. Scrutiny of vertebrate cDNA sequences in light of these …

A central issue in the study of neoplastic transformation is to understand how proto-
oncogene products deregulate normal processes of cell growth and differentiation; an …

T lymphocytes express a tyrosine protein kinase (TPK; protein-tyrosine kinase; ATP: protein-
tyrosine O-phosphotransferase, EC 2.7. 1.112), pp56lck that is encoded by the lck …

There is increasing evidence that deregulation of gene expression at the level of mRNA
translation can contribute to cell transformation and the malignant phenotype. Two steps in …