Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans

M Kodali, T Jankay, AK Shetty, DS Reddy - Psychopharmacology, 2023 - Springer
This article describes the pathophysiology and potential treatments for Gulf War Illness
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …

[HTML][HTML] Soil Chemical Pollution and Military Actions: A Bibliometric Analysis

T Stadler, Á Temesi, Z Lakner - Sustainability, 2022 - mdpi.com
Contrary to the optimistic expectations three decades ago, global military expenditure is
increasing rather rapidly, fueled by the increasing intensity of international tensions. As a …

[HTML][HTML] Impact of gulf war toxic exposures after mild traumatic brain injury

S Ferguson, R McCartan, M Browning… - Acta Neuropathologica …, 2022 - Springer
Chemical and pharmaceutical exposures have been associated with the development of
Gulf War Illness (GWI), but how these factors interact with the pathophysiology of traumatic …

Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a …

A Ribeiro-Davis, DY Al Saeedy, FM Jahr… - … of Pharmacology and …, 2024 - ASPET
Approximately one-third of Gulf War veterans suffer from Gulf War Illness (GWI), which
encompasses mood disorders and depressive symptoms. Deployment-related exposure to …

Repeated exposure to chlorpyrifos is associated with a dose-dependent chronic neurobehavioral deficit in adult rats

ACR Ribeiro, E Hawkins, FM Jahr, JL McClay… - Neurotoxicology, 2022 - Elsevier
Organophosphate (OP) chemicals include commonly used pesticides and chemical warfare
agents, and mechanistically they are potent inhibitors of the cholinesterase (ChE) enzyme …

The connection between epigenetics and gut microbiota‐current perspective

X Yuan, Y Tan, O Bajinka, ML Jammeh… - Cell Biochemistry …, 2024 - Wiley Online Library
Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in
establishing effective diagnostics and potential therapeutic strategies for a number of …

Exposing the latent phenotype of Gulf War Illness: examination of the mechanistic mediators of cognitive dysfunction

HE Burzynski, LP Reagan - Frontiers in Immunology, 2024 - frontiersin.org
Though it has been over 30 years since the 1990–1991 Gulf War (GW), the pathophysiology
of Gulf War Illness (GWI), the complex, progressive illness affecting approximately 30% of …

Experimental Models of Gulf War Illness, a Chronic Neuropsychiatric Disorder in Veterans

DS Reddy, X Wu, T Singh, M Neff - Current Protocols, 2023 - Wiley Online Library
Gulf War illness (GWI) is a chronic multifaceted condition with debilitating pain and fatigue,
as well as sleep, behavioral, and cognitive impairments in war veterans. Currently, there is …

[HTML][HTML] A Double-Humanized Mouse Model for Studying Host Gut Microbiome–Immune Interactions in Gulf War Illness

D Bose, P Saha, S Roy, A Trivedi, M More… - International Journal of …, 2024 - mdpi.com
Unraveling the multisymptomatic Gulf War Illness (GWI) pathology and finding an effective
cure have eluded researchers for decades. The chronic symptom persistence and limitations …

Living With Toxic Wounds: The Voices and Visual Self-Representations of Gulf War Veterans

R Dieterich-Hartwell, B Malhotra… - Qualitative health …, 2024 - journals.sagepub.com
Operations Desert Shield and Storm occurred over 30 years ago, yet many of those who
were deployed continue to experience chronic and debilitating symptoms, now recognized …