TET enzymes, TDG and the dynamics of DNA demethylation
DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …
Although enzymes that catalyse DNA methylation have been well characterized, those that …
An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity
D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
Cytosine methylation is the major covalent modification of mammalian genomic DNA and
plays important roles in transcriptional regulation. The molecular mechanism underlying the …
plays important roles in transcriptional regulation. The molecular mechanism underlying the …
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
J Feng, Y Zhou, SL Campbell, T Le, E Li… - Nature …, 2010 - nature.com
Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …
Neuronal activity modifies the DNA methylation landscape in the adult brain
DNA methylation has been traditionally viewed as a highly stable epigenetic mark in
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …
Gadd45 in stress signaling, cell cycle control, and apoptosis
The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is
often induced by DNA damage and other stress signals associated with growth arrest and …
often induced by DNA damage and other stress signals associated with growth arrest and …
The role of DNA methylation in stress-related psychiatric disorders
Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …
important factors in the long-term biological trajectories leading to stress-related psychiatric …
Epigenetics, plasticity, and evolution: How do we link epigenetic change to phenotype?
EJ Duncan, PD Gluckman… - Journal of Experimental …, 2014 - Wiley Online Library
Epigenetic mechanisms are proposed as an important way in which the genome responds
to the environment. Epigenetic marks, including DNA methylation and Histone modifications …
to the environment. Epigenetic marks, including DNA methylation and Histone modifications …
The effects of early life stress on the epigenome: from the womb to adulthood and even before
N Provençal, EB Binder - Experimental neurology, 2015 - Elsevier
Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …
established major risk factor for developing psychiatric and behavioral disorders later in life …
DNA methylation and memory formation
JJ Day, JD Sweatt - Nature neuroscience, 2010 - nature.com
Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …