DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Cytosine methylation is the major covalent modification of mammalian genomic DNA and
plays important roles in transcriptional regulation. The molecular mechanism underlying the …

Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …

DNA methylation has been traditionally viewed as a highly stable epigenetic mark in
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …

The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is
often induced by DNA damage and other stress signals associated with growth arrest and …

Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …

Epigenetic mechanisms are proposed as an important way in which the genome responds
to the environment. Epigenetic marks, including DNA methylation and Histone modifications …

Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …

Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …