I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Background Chronic rhinosinusitis (CRS) is based on sinonasal symptoms coupled with
sinonasal tissue inflammation. Establishing the epidemiology and prevalence of CRS …

Objective/Study Design The objective of this systematic review was to summarize the
literature evaluating the costs associated with the management of adult chronic …

The accurate diagnosis of rhinologic disease depends on the clinical history, examination
findings and, in many cases, further investigations. There are a wide variety of diagnostic …

Objectives/Hypothesis The 22‐item Sinonasal Outcome Test (SNOT‐22) is a validated
chronic rhinosinusitis health‐related quality‐of‐life outcome (HRQoL) measure; however …

Background With a focus on patient-centered care, there is increasing policy interest in
patient-reported outcome measures (PROMs) to inform improvements in health care …

Objective Both endoscopic sinus surgery (ESS) and biologic therapies have shown
effectiveness for medically‐refractory chronic rhinosinusitis with nasal polyps (CRSwNP) …

Background Prior work has described 5 domains within the 22‐item Sino‐Nasal Outcomes
Test (SNOT‐22) that allow for stratification of symptoms into similar clusters and that can be …

Objectives/Hypothesis The goal of the study was to perform a systematic review with meta‐
analysis to determine the mean change in the 22‐item Sino‐Nasal Outcome Test (SNOT …

Rationale: Elexacaftor, tezacaftor, and ivacaftor (ETI) in triple combination improves
pulmonary health for people with cystic fibrosis (PwCF). However, its impact on objective …