The allene functionality has participated in one of the most exciting voyages in organic
chemistry, from chemical curiosities to a recurring building block in modern organic …

The discovery of penicillin by Sir Alexander Fleming in 1928 provided us with access to a
new class of compounds useful at fighting bacterial infections: antibiotics. Ever since, a …

Archangiumide is the first known macrolide natural product comprising an endocyclic allene.
For the ring strain that this linear substructure might entail, it was planned to unveil the …

The metathesis reactions, in their various versions, have become a powerful and extremely
valuable tool for the formation of carbon–carbon bonds in organic synthesis. The plethora of …

The first synthesis of the protected chain specific to the enacyloxin antibiotic family is
reported. The noticeable features are (a) the construction of the chlorinated …

Transition-metal-catalyzed cross-coupling of organohalides, ethers, sulfides, amines, and
alcohols (and derivatives thereof) with Grignard reagents, known as the Kumada–Tamao …

Fidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides
difficile and other Gram‐positive bacteria such as Mycobacterium tuberculosis. Only a few …

The passion of total‐and fragments syntheses of natural products always remained one of
the top priorities among the synthetic chemists worldwide. Due their curiosity toward the …

The macrocyclic antibiotic mangrolide A has been described to exhibit potent activity against
a number of clinically important Gram‐negative pathogens. Reported is the first …

A total synthesis of tiacumicin B, a natural macrolide whose remarkable antibiotic properties
are used to treat severe intestinal infections, is reported. The strategy is in part based on the …