[HTML][HTML] Insulin signaling in health and disease
AR Saltiel - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …
Biochemical and cellular properties of insulin receptor signalling
RA Haeusler, TE McGraw, D Accili - Nature reviews Molecular cell …, 2018 - nature.com
The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
[HTML][HTML] Antidiabetic properties of dietary flavonoids: a cellular mechanism review
R Vinayagam, B Xu - Nutrition & metabolism, 2015 - Springer
Background Natural food products have been used for combating human diseases for
thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones …
thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones …
Insulin receptor signaling in normal and insulin-resistant states
J Boucher, A Kleinridders… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …
understanding the signaling pathways impacting this disease. Insulin signaling regulates …
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
HT McMahon, E Boucrot - Nature reviews Molecular cell biology, 2011 - nature.com
Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
AK Manning, MF Hivert, RA Scott, JL Grimsby… - Nature …, 2012 - nature.com
Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …
Insulin signalling and the regulation of glucose and lipid metabolism
AR Saltiel, CR Kahn - Nature, 2001 - nature.com
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …
The phosphoinositide 3-kinase pathway
LC Cantley - Science, 2002 - science.org
Phosphorylated lipids are produced at cellular membranes during signaling events and
contribute to the recruitment and activation of various signaling components. The role of …
contribute to the recruitment and activation of various signaling components. The role of …
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
H Khodabandehloo, S Gorgani-Firuzjaee… - Translational …, 2016 - Elsevier
Obesity is a major public health problem worldwide, and it is associated with an increased
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …