Fluorouracil (5-FU) is an essential component of systemic chemotherapy for colorectal
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …

Colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in
both men and women worldwide. This is in spite of widespread, effective measures of …

Simple Summary Chemotherapy, radiotherapy and molecularly targeted therapy could
improve the prognosis of colorectal cancer (CRC) patients. Recently, immunotherapy …

Frequent development of resistance to chemotherapeutic agents such as 5-flourouracil (5-
FU) complicates the treatment of advanced colorectal cancer (CRC). Resveratrol is able to …

Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

The number of agents that are potentially effective in the adjuvant treatment of locally
advanced resectable colon cancer is increasing. Consequently, it is important to ascertain …

Background Colorectal cancer (CRC) is a disease with high morbidity and mortality rates. 5-
fluorouracil (5-FU) is the first-line recommended drug for chemotherapy in patients with …

Colorectal cancer is the second leading cause of cancer-related deaths in the world. Despite
many therapeutic opportunities, prognosis remains dismal for patients with metastatic …

Thymidylate synthase is the rate-limiting enzyme required for DNA synthesis and
overexpression of this enzyme causes resistance to cancer cells. Long treatments with 5-FU …