An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

Over the past two decades, there has been a growing interest in the use of plasmonic
nanoparticles as sources of heat remotely controlled by light, giving rise to the field of …

Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …

Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby
triggering the type Ι interferon (IFN) response. Mitochondrial outer membrane …

DNA and histone modifications have notable effects on gene expression. Being the most
prevalent internal modification in mRNA, the N 6-methyladenosine (m6A) mRNA …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …

Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …

Inspired by the success of dual-targeting drugs, especially bispecific antibodies, we propose
to combine the concept of proteolysis targeting chimera (PROTAC) and dual targeting to …

ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against
xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance …