Chemical and biophysical signatures of the protein corona in nanomedicine
J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …
collection of biomolecular species by nanoparticles in living systems. The protein corona is …
Applications and challenges of thermoplasmonics
Over the past two decades, there has been a growing interest in the use of plasmonic
nanoparticles as sources of heat remotely controlled by light, giving rise to the field of …
nanoparticles as sources of heat remotely controlled by light, giving rise to the field of …
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
R Moliner, M Girych, CA Brunello, V Kovaleva… - Nature …, 2023 - nature.com
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …
resembling the effects of clinically approved antidepressants. We recently reported that …
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
J Kim, R Gupta, LP Blanco, S Yang… - Science, 2019 - science.org
Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby
triggering the type Ι interferon (IFN) response. Mitochondrial outer membrane …
triggering the type Ι interferon (IFN) response. Mitochondrial outer membrane …
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
DNA and histone modifications have notable effects on gene expression. Being the most
prevalent internal modification in mRNA, the N 6-methyladenosine (m6A) mRNA …
prevalent internal modification in mRNA, the N 6-methyladenosine (m6A) mRNA …
Emerging degrader technologies engaging lysosomal pathways
Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …
Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
N Miao, Z Wang, Q Wang, H Xie, N Yang… - Nature …, 2023 - nature.com
Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …
Theory and applications of differential scanning fluorimetry in early-stage drug discovery
K Gao, R Oerlemans, MR Groves - Biophysical reviews, 2020 - Springer
Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …
technique that has seen many applications over the years, ranging from protein folding state …
Rational design and synthesis of novel dual PROTACs for simultaneous degradation of EGFR and PARP
M Zheng, J Huo, X Gu, Y Wang, C Wu… - Journal of Medicinal …, 2021 - ACS Publications
Inspired by the success of dual-targeting drugs, especially bispecific antibodies, we propose
to combine the concept of proteolysis targeting chimera (PROTAC) and dual targeting to …
to combine the concept of proteolysis targeting chimera (PROTAC) and dual targeting to …
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2
SM Jackson, I Manolaridis, J Kowal… - Nature structural & …, 2018 - nature.com
ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against
xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance …
xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance …