Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Beta-lactam antibiotics serve as a cornerstone in the management of bacterial infections
because of their wide spectrum of activity and low toxicity. Since resistance rates among …

Piperacillin-tazobactam is often given to infants with severe infection in spite of limited
pharmacokinetics (PK) data. We evaluated piperacillin-tazobactam PK in premature and …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …

Antibiotics are often used in neonates despite the absence of relevant dosing information in
drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and …

The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics
of piperacillin and tazobactam administered by prolonged infusion in obese patients …

Studies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …

Purpose Pseudomonas aeruginosa is a commonly isolated nosocomial pathogen for which
treatment options are often limited for multidrug-resistant isolates. In addition to newer …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

Abstract Background/Objectives Febrile neutropenia (FN) occurs in up to 80% of patients
with hematologic malignancies. Evidence suggests using extended infusions (EI) of beta …