Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk
J Lake, X Reed, RG Langston, MA Nalls… - Movement …, 2022 - Wiley Online Library
Background The leucine‐rich repeat kinase 2 (LRRK2) gene harbors both rare highly
damaging missense variants (eg, p. G2019S) and common noncoding variants (eg …
damaging missense variants (eg, p. G2019S) and common noncoding variants (eg …
[HTML][HTML] M1 microglia-derived exosomes promote activation of resting microglia and amplifies proangiogenic effects through Irf1/miR-155-5p/Socs1 axis in the retina
X Chen, X Wang, Z Cui, Q Luo, Z Jiang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Activation of microglia plays a key role in the development of neovascular retinal diseases.
Therefore, it is essential to reveal its pathophysiological and molecular mechanisms to …
Therefore, it is essential to reveal its pathophysiological and molecular mechanisms to …
Human peripheral monocytes capture elements of the state of microglial activation in the brain
Despite a growing focus on neuroimmune mechanisms of Alzheimer's disease (AD), the role
of peripheral monocytes remains largely unknown. Circulating monocytes communicate with …
of peripheral monocytes remains largely unknown. Circulating monocytes communicate with …
LRRK2 coding variants and the risk of Parkinson's disease
Background The leucine-rich repeat kinase 2 (LRRK2) gene harbors both rare highly
damaging missense variants (egp G2019S) and common non-coding variants (eg …
damaging missense variants (egp G2019S) and common non-coding variants (eg …