Growth hormone action in somatostatin neurons regulates anxiety and fear memory

WO Dos Santos, VAL Juliano, FM Chaves… - Journal of …, 2023 - Soc Neuroscience
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …

New findings on brain actions of growth hormone and potential clinical implications

J Donato Jr, JJ Kopchick - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The
classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth …

Central growth hormone action regulates neuroglial and proinflammatory markers in the hypothalamus of male mice

F Wasinski, MR Tavares, DO Gusmao, EO List… - Neuroscience …, 2023 - Elsevier
Growth hormone (GH) action in specific neuronal populations regulates neuroendocrine
responses, metabolism, and behavior. However, the potential role of central GH action on …

Endocrine regulation of aging: impacts of humoral factors and circulating mediators

B Petersen, S Negri, M Milan, Z Reyff… - Frontiers in …, 2024 - frontiersin.org
The intersection of endocrine regulation and aging merges two intricate and
multidimensional fields of research, a convergence that is crucial in unraveling the biological …

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction

GO de Souza, PDS Teixeira, NOS Câmara, J Donato Jr - Cells, 2023 - mdpi.com
Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the
agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive …

The Pattern of GH Action in the Mouse Brain

F Menezes, F Wasinski, GO de Souza, AP Nunes… - …, 2024 - academic.oup.com
Growth hormone (GH) acts in numerous organs expressing the GH receptor (GHR),
including the brain. However, the mechanisms behind the brain's permeability to GH and …