Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Alternative splicing, an Overlooked Defense Frontier of Plants with respect to bacterial infection

JQ Xie, X Zhou, ZC Jia, CF Su, Y Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Disease represents a major problem in sustainable agricultural development. Plants interact
closely with various microorganisms during their development and in response to the …

Deregulated microRNAs involved in prostate cancer aggressiveness and treatment resistance mechanisms

H Gujrati, S Ha, BD Wang - Cancers, 2023 - mdpi.com
Simple Summary Accumulating studies have highlighted the critical roles of microRNAs in
tumorigenesis and cancer treatment responses. Here, we systematically review the scientific …

Osteopontin and cancer: insights into its role in drug resistance

C Hao, J Lane, WG Jiang - Biomedicines, 2023 - mdpi.com
Cancer is one of the leading causes of mortality worldwide. Currently, drug resistance is the
main obstacle in cancer treatments with the underlying mechanisms of drug resistance yet to …

[HTML][HTML] The interplay between non-coding RNAs and alternative splicing: from regulatory mechanism to therapeutic implications in cancer

M Liu, S Zhang, H Zhou, X Hu, J Li, B Fu, M Wei… - Theranostics, 2023 - ncbi.nlm.nih.gov
Alternative splicing (AS) is a common and conserved process in eukaryotic gene regulation.
It occurs in approximately 95% of multi-exon genes, greatly enriching the complexity and …

Competing endogenous RNA (ceRNA) networks and splicing switches in cervical cancer: HPV oncogenesis, clinical significance and therapeutic opportunities

A Basera, R Hull, D Demetriou, DO Bates… - Microorganisms, 2022 - mdpi.com
Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income
countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in …

Chemotherapeutic drug resistance associated with differential miRNA expression of miR-375 and miR-27 among oral cancer cell lines

KC Huni, J Cheung, M Sullivan, WT Robison… - International Journal of …, 2023 - mdpi.com
Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-
145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral …

Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling

Y Gu, X Feng, Y Jin, Y Liu, L Zeng… - Journal of Obstetrics …, 2023 - Taylor & Francis
Cervical cancer (CC) is a common malignant neoplasm in gynecology. There is increasing
evidence to suggest that microRNAs (miRNAs) act as crucial regulators of CC. However …

Targeted splicing therapy: new strategies for colorectal cancer

Y Zheng, G Zhong, C He, M Li - Frontiers in Oncology, 2023 - frontiersin.org
RNA splicing is the process of forming mature mRNA, which is an essential phase
necessary for gene expression and controls many aspects of cell proliferation, survival, and …

RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration

CM Di Liegro, G Schiera, G Schirò… - International Journal of …, 2022 - mdpi.com
A central aspect of nervous system development and function is the post-transcriptional
regulation of mRNA fate, which implies time-and site-dependent translation, in response to …