Gene expression patterns in cancer cells are strongly influenced by posttranscriptional
mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene …

Genome integrity must be tightly preserved to ensure cellular survival and to deter the
genesis of disease. Endogenous and exogenous stressors that impose threats to genomic …

As the most critical alternative splicing regulator, heterogeneous nuclear ribonucleoproteins
(hnRNPs) have been reported to be implicated in various aspects of cancer. However, the …

Rationale: The 14-3-3 protein family is known to interact with many proteins in non-cardiac
cell types to regulate multiple signaling pathways, particularly those relating to energy and …

RNA-binding proteins (RBPs) are evolutionarily conserved across most forms of life, with an
estimated 1,500 RBPs in humans. Traditionally associated with post-transcriptional gene …

Background Dysregulations in alternative splicing (AS) patterns have been associated with
many human diseases including cancer. In the present study, alterations to the global RNA …

A shared characteristic of many tumors is the lack of response to anticancer drugs. Multiple
mechanisms of pharmacoresistance (MPRs) are involved in permitting cancer cells to …

Alternative splicing dysregulation is an emerging cancer hallmark, potentially serving as a
source of novel diagnostic, prognostic, or therapeutic tools. Inhibitors of the activity of the …

Therapeutic resistance is the major contributor to the poor prognosis of and low survival from
pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions …

Abstract Heterogeneous Ribonucleoprotein D (hnRNPD) is an RNA binding protein involved
in post-transcriptional regulation of multiple mediators of carcinogenesis. We previously …