Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …

BACE1 was discovered as the β-secretase for initiating the cleavage of amyloid precursor
protein (APP) at the β-secretase site, while its close homology BACE2 cleaves APP within …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness
among the elderly population. To accelerate the understanding of the genetics of AMD, we …

Background Two main genetic risks for sporadic Alzheimer's disease (AD) are a family
history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous …

There is increasing awareness on the role played by circadian rhythm abnormalities in
neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease …

Alzheimer's disease (AD) of the brain neocortex and age-related macular degeneration
(AMD) of the retina are two complex neurodegenerative disorders, which (i) involve the …

Relevance. Age-related macular degeneration (AMD) and glaucoma are currently the main
causes of irreversible vision loss in developed countries. Purpose. To study the …

In Alzheimer's disease (AD), vascular changes could be caused by amyloid beta (Aβ)
aggregates replacing the contractile smooth musculature of the arteriole walls. These …

Alzheimer's disease (AD) is the most common form of dementia that remains incurable and
has become a major medical, social, and economic challenge worldwide. AD is …

Background: Emerging neuroprotective strategies are being explored to preserve the retina
from degeneration, that occurs in eye pathologies like glaucoma, diabetic retinopathy, age …