Serial femtosecond crystallography
TRM Barends, B Stauch, V Cherezov… - Nature reviews Methods …, 2022 - nature.com
With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …
crystallography techniques for macromolecular structure determination have emerged …
[HTML][HTML] β-Lactamases and β-Lactamase Inhibitors in the 21st Century
The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
A MHz-repetition-rate hard X-ray free-electron laser driven by a superconducting linear accelerator
W Decking, S Abeghyan, P Abramian, A Abramsky… - Nature …, 2020 - nature.com
The European XFEL is a hard X-ray free-electron laser (FEL) based on a high-electron-
energy superconducting linear accelerator. The superconducting technology allows for the …
energy superconducting linear accelerator. The superconducting technology allows for the …
Chemical crystallography by serial femtosecond X-ray diffraction
EA Schriber, DW Paley, R Bolotovsky, DJ Rosenberg… - Nature, 2022 - nature.com
Inorganic–organic hybrid materials represent a large share of newly reported structures,
owing to their simple synthetic routes and customizable properties. This proliferation has led …
owing to their simple synthetic routes and customizable properties. This proliferation has led …
[HTML][HTML] 10 years of pioneering X-ray science at the Free-Electron Laser FLASH at DESY
J Rossbach, JR Schneider, W Wurth - Physics reports, 2019 - Elsevier
Free-electron lasers produce extremely brief, coherent, and bright laser-like photon pulses
that allow to image matter at atomic resolution and at timescales faster than the …
that allow to image matter at atomic resolution and at timescales faster than the …
Ultracompact 3D microfluidics for time-resolved structural biology
To advance microfluidic integration, we present the use of two-photon additive
manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with …
manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with …
[HTML][HTML] Recent results in time resolved serial femtosecond crystallography at XFELs
AM Orville - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Time-resolved serial femtosecond crystallography (tr-SFX) probes structure and
function in each sample.•X-ray free electron lasers (XFELS) provide atomic and electronic …
function in each sample.•X-ray free electron lasers (XFELS) provide atomic and electronic …
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …
X-ray free-electron lasers for the structure and dynamics of macromolecules
HN Chapman - Annual review of biochemistry, 2019 - annualreviews.org
X-ray free-electron lasers provide femtosecond-duration pulses of hard X-rays with a peak
brightness approximately one billion times greater than is available at synchrotron radiation …
brightness approximately one billion times greater than is available at synchrotron radiation …
Time-resolved serial femtosecond crystallography at the European XFEL
Abstract The European XFEL (EuXFEL) is a 3.4-km long X-ray source, which produces
femtosecond, ultrabrilliant and spatially coherent X-ray pulses at megahertz (MHz) repetition …
femtosecond, ultrabrilliant and spatially coherent X-ray pulses at megahertz (MHz) repetition …