Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …
Biomaterials as vectors for the delivery of CRISPR–Cas9
The emergence of the CRISPR–Cas9 gene editing system has brought much hope and
excitement to the field of gene therapy and the larger scientific community. However, in order …
excitement to the field of gene therapy and the larger scientific community. However, in order …
[HTML][HTML] SAMHD1 acts at stalled replication forks to prevent interferon induction
SAMHD1 was previously characterized as a dNTPase that protects cells from viral infections.
Mutations in SAMHD1 are implicated in cancer development and in a severe congenital …
Mutations in SAMHD1 are implicated in cancer development and in a severe congenital …
[HTML][HTML] STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain
Following the detection of cytosolic double-stranded DNA from viral or bacterial infection in
mammalian cells, cyclic dinucleotide activation of STING induces interferon β expression to …
mammalian cells, cyclic dinucleotide activation of STING induces interferon β expression to …
Middle East respiratory coronavirus accessory protein 4a inhibits PKR-mediated antiviral stress responses
HH Rabouw, MA Langereis, RCM Knaap… - PLoS …, 2016 - journals.plos.org
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory
infections that can be life-threatening. To establish an infection and spread, MERS-CoV, like …
infections that can be life-threatening. To establish an infection and spread, MERS-CoV, like …
Cell attachment domains of the porcine epidemic diarrhea virus spike protein are key targets of neutralizing antibodies
C Li, W Li, E Lucio de Esesarte, H Guo… - Journal of …, 2017 - Am Soc Microbiol
Porcine epidemic diarrhea virus (PEDV) causes enteric disease in pigs, resulting in
significant economic losses to the swine industry worldwide. Current vaccination …
significant economic losses to the swine industry worldwide. Current vaccination …
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry
Porcine epidemic diarrhea virus (PEDV) is an emerging pathogenic coronavirus that causes
a significant economic burden to the swine industry. The virus infects the intestinal …
a significant economic burden to the swine industry. The virus infects the intestinal …
MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes
X Li, NMC Bleumink-Pluym, YMCA Luijkx… - PLoS …, 2019 - journals.plos.org
The cellular invasion machinery of the enteric pathogen Salmonella consists of a type III
secretion system (T3SS) with injectable virulence factors that induce uptake by …
secretion system (T3SS) with injectable virulence factors that induce uptake by …
Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathway
Despite only comprising half of all known viral species, RNA viruses are disproportionately
responsible for many of the worst epidemics in human history, including outbreaks of …
responsible for many of the worst epidemics in human history, including outbreaks of …
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system
The newly emerged severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)
coronavirus initiated a pneumonia outbreak (COVID-19) that rapidly spread worldwide and …
coronavirus initiated a pneumonia outbreak (COVID-19) that rapidly spread worldwide and …