Sex-gender variable: methodological recommendations for increasing scientific value of clinical studies

F Franconi, I Campesi, D Colombo, P Antonini - Cells, 2019 - mdpi.com
There is a clear sex–gender gap in the prevention and occurrence of diseases, and in the
outcomes and treatments, which is relevant to women in the majority of cases. Attitudes …

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

HB Beyene, G Olshansky, AA T. Smith, C Giles… - PLoS …, 2020 - journals.plos.org
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

The majority of male patients with COVID-19 present low testosterone levels on admission to Intensive Care in Hamburg, Germany: a retrospective cohort study

M Schroeder, B Tuku, D Jarczak, A Nierhaus, T Bai… - MedRxiv, 2020 - medrxiv.org
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to
spread worldwide and pose a major public health burden. There is increasing evidence that …

Exposomics as a tool to investigate differences in health and disease by sex and gender

ML Bucher, FL Anderson, Y Lai, J Dicent, GW Miller… - …, 2023 - academic.oup.com
The health and disease of an individual is mediated by their genetics, a lifetime of
environmental exposures, and interactions between the two. Genetic or biological sex …

LC/MS-based untargeted metabolomics analysis in women with morbid obesity and associated type 2 diabetes mellitus

T Auguet, L Bertran, J Capellades, S Abelló… - International Journal of …, 2023 - mdpi.com
Obesity is a chronic and complex disease, with an increasing incidence worldwide that is
associated with metabolic disorders such as type 2 diabetes mellitus (T2DM). Thus, it is …

Cooperative p16 and p21 action protects female astrocytes from transformation

N Kfoury, T Sun, K Yu, N Rockwell, KL Tinkum… - Acta neuropathologica …, 2018 - Springer
Mechanisms underlying sex differences in cancer incidence are not defined but likely
involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As …

Metabolomic determinants of metabolic risk in Mexican adolescents

W Perng, EC Hector, PXK Song, MM Tellez Rojo… - …, 2017 - Wiley Online Library
Objective The goal of this study was to identify metabolites associated with metabolic risk,
separately by sex, in Mexican adolescents. Methods Untargeted metabolomic profiling was …

Methylome and transcriptome profiling revealed epigenetic silencing of LPCAT1 and PCYT1A associated with lipidome alterations in polycystic ovary syndrome

Z Mao, T Li, H Zhao, X Wang, Y Kang… - Journal of Cellular …, 2021 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrine diseases of fertile women
and a major cause of infertility. The regulatory effects of DNA methylation on gene …

New perspectives on 'Breathomics': metabolomic profiling of non-volatile organic compounds in exhaled breath using DI-FT-ICR-MS

M Malik, T Demetrowitsch, K Schwarz… - Communications …, 2024 - nature.com
Breath analysis offers tremendous potential for diagnostic approaches, since it allows for
easy and non-invasive sample collection.“Breathomics” as one major research field …

Sexual dimorphism in body weight loss, improvements in cardiometabolic risk factors and maintenance of beneficial effects 6 months after a low-calorie diet: Results …

I Trouwborst, GH Goossens, A Astrup, WHM Saris… - Nutrients, 2021 - mdpi.com
A low-calorie diet (LCD) is an effective strategy to lose weight and improve cardiometabolic
risk factors, however, sexual dimorphism may be present. This study aims to investigate …