[HTML][HTML] The hallmarks of aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …
function and increased vulnerability to death. This deterioration is the primary risk factor for …
The BCL2 family: key mediators of the apoptotic response to targeted anticancer therapeutics
The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …
Forkhead box proteins: tuning forks for transcriptional harmony
EWF Lam, JJ Brosens, AR Gomes, CY Koo - Nature Reviews Cancer, 2013 - nature.com
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …
fine-tuning the spatial and temporal expression of a broad range of genes both during …
[HTML][HTML] Akt, FoxO and regulation of apoptosis
X Zhang, N Tang, TJ Hadden, AK Rishi - Biochimica et Biophysica Acta …, 2011 - Elsevier
Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine
protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and …
protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and …
FOXO3: a major gene for human longevity-a mini-review
Background: The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3),
is one of only two for which genetic polymorphisms have exhibited consistent associations …
is one of only two for which genetic polymorphisms have exhibited consistent associations …
FOXO transcription factors: their clinical significance and regulation
Y Wang, Y Zhou, DT Graves - BioMed research international, 2014 - Wiley Online Library
Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
FOXO transcription factors in cancer development and therapy
A Coomans de Brachène, JB Demoulin - Cellular and molecular life …, 2016 - Springer
The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that
limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in …
limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in …
The emerging roles of forkhead box (Fox) proteins in cancer
SS Myatt, EWF Lam - Nature Reviews Cancer, 2007 - nature.com
Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional
regulators, which control a wide spectrum of biological processes. As a consequence, a loss …
regulators, which control a wide spectrum of biological processes. As a consequence, a loss …
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
S Kume, T Uzu, K Horiike… - The Journal of …, 2010 - Am Soc Clin Investig
Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the …
demonstrate that this process is attenuated by calorie restriction (CR). However, the …
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer
SP Tenbaum, P Ordóñez-Morán, I Puig, I Chicote… - Nature medicine, 2012 - nature.com
The Wnt–β-catenin and PI3K-AKT-FOXO3a pathways have a central role in cancer. AKT
phosporylates FOXO3a, relocating it from the cell nucleus to the cytoplasm, an effect that is …
phosporylates FOXO3a, relocating it from the cell nucleus to the cytoplasm, an effect that is …