Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …

Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine
protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and …

Background: The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3),
is one of only two for which genetic polymorphisms have exhibited consistent associations …

Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …

The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that
limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in …

Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional
regulators, which control a wide spectrum of biological processes. As a consequence, a loss …

Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the …

The Wnt–β-catenin and PI3K-AKT-FOXO3a pathways have a central role in cancer. AKT
phosporylates FOXO3a, relocating it from the cell nucleus to the cytoplasm, an effect that is …