Coronary artery disease (CAD) is one of the major cardiovascular diseases affecting the
global human population. This disease has been proved to be the major cause of death in …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

ATP-binding cassette (ABC) transporters are involved in active pumping of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …

Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of
phospholipids and cholesterol to the extracellular acceptor apolipoprotein AI (apoA-I) for …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …

Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33,
an intronic microRNA (miRNA) located within the gene encoding sterol-regulatory element …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …