Resolution of pulmonary edema. Thirty years of progress

MA Matthay - American journal of respiratory and critical care …, 2014 - atsjournals.org
In the last 30 years, we have learned much about the molecular, cellular, and physiological
mechanisms that regulate the resolution of pulmonary edema in both the normal and the …

High-altitude pulmonary edema

ER Swenson - Textbook of pulmonary vascular disease, 2011 - Springer
High-altitude pulmonary edema (HAPE) is an uncommon form of pulmonary edema that
occurs in healthy individuals within a few days of arrival at altitudes above 2,500–3,000 m …

The contribution of epithelial sodium channels to alveolar function in health and disease

DC Eaton, MYN Helms, M Koval… - Annual review of …, 2009 - annualreviews.org
Amiloride-sensitive epithelial sodium channels (ENaC) play an important role in lung
sodium transport. Sodium transport is closely regulated to maintain an appropriate fluid layer …

[HTML][HTML] S-nitroso-L-cysteine stereoselectively blunts the adverse effects of morphine on breathing and arterial blood gas chemistry while promoting analgesia

PM Getsy, AP Young, JN Bates, SM Baby… - Biomedicine & …, 2022 - Elsevier
S-nitrosothiols exert multiple effects on neural processes in the central and peripheral
nervous system. This study shows that intravenous infusion of S-nitroso-L-cysteine (SNO-L …

[HTML][HTML] Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis

JD Brand, A Lazrak, JE Trombley, RJ Shei… - JCI insight, 2018 - ncbi.nlm.nih.gov
Severe influenza (IAV) infection can develop into bronchopneumonia and edema, leading to
acquired respiratory distress syndrome (ARDS) and pathophysiology. Underlying causes for …

Angiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney

P Sun, P Yue, WH Wang - American Journal of Physiology …, 2012 - journals.physiology.org
We examined the effect of angiotensin II (ANG II) on epithelial Na+ channel (ENaC) in the rat
cortical collecting duct (CCD) with single-channel and the perforated whole cell patch-clamp …

Regulation of lung epithelial sodium channels by cytokines and chemokines

BM Wynne, L Zou, V Linck, RS Hoover, HP Ma… - Frontiers in …, 2017 - frontiersin.org
Acute lung injury leading to acute respiratory distress (ARDS) is a global health concern.
ARDS patients have significant pulmonary inflammation leading to flooding of the pulmonary …

Influenza virus infection alters ion channel function of airway and alveolar cells: mechanisms and physiological sequelae

JD Londino, A Lazrak, JF Collawn… - … of Physiology-Lung …, 2017 - journals.physiology.org
The cystic fibrosis transmembrane conductance regulator (CFTR) and the amiloride-
sensitive epithelial sodium channels (ENaC) are located in the apical membranes of airway …

In vitro lung slices: a powerful approach for assessment of lung pathophysiology

TA Liberati, MR Randle, LA Toth - Expert review of molecular …, 2010 - Taylor & Francis
This review summarizes the existing literature on the use of in vitro lung slices to study
pulmonary physiology, pharmacology, pathogenesis and toxicity. Since in vitro lung slices …

Cytokine–ion channel interactions in pulmonary inflammation

J Hamacher, Y Hadizamani, M Borgmann… - Frontiers in …, 2018 - frontiersin.org
The lungs conceptually represent a sponge that is interposed in series in the bodies'
systemic circulation to take up oxygen and eliminate carbon dioxide. As such, it matches the …