Personalized medicine is focused on research disciplines which contribute to the
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …

Background Numerous different types of variations can occur in DNA and have diverse
effects and consequences. The Variation Ontology (VariO) was developed for systematic …

The UGT1A1 enzyme is involved in the metabolism of bilirubin and numerous medications.
Unconjugated hyperbilirubinemia, commonly presented as Gilbert syndrome (GS), is a result …

In humans, like every other organism, there is huge interindividual variability, resulting in
approximately 3.5–5 million naturally occurring genomic variants observed per genome …

Non-pharmacological treatment including diet, body weight reduction, smoking cessation
and physical activity, is very important part of hypertension treatment. The objective of this …

Among microcytic hypochromic anemias, the most common disorders are iron deficiency
anemia and co-pathological conditions such as α-or β-thalassemia (α-or β-thal) traits. The …

Oculocutaneous albinism (OCA) is an inherited disorder affecting the visual system and skin
pigmentation. Our aim was to evaluate genetic and clinical heterogeneity in a cohort of …

Aim: Microbiota–host–xenobiotics interactions in humans become of prime interest when
clinical pharmacogenomics is to be implemented. Despite the advent of technology …

Abstract FINDbase (http://www. findbase. org) is a comprehensive data resource recording
the prevalence of clinically relevant genomic variants in various populations worldwide …

Original ideas and innovation cannot always be ordered like a courier service and delivered
fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions …