Tumor cells mainly provide necessary energy and substances for rapid cell growth through
aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the …

Glycolysis is a complex metabolic process that occurs to convert glucose into pyruvate to
produce energy for living cells. Normal cells oxidized pyruvate into adenosine triphosphate …

Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty
liver disease (NAFLD), and inhibitors of this enzyme could represent a new therapeutic …

Glutathione reductase (GR) is a major antioxidant enzyme essential to maintain GSH/GSSG
ratio by catalyzing recovery of reduced glutathione (GSH) from oxidized glutathione (GSSG) …

Multiple lines of evidence have indicated that pyruvate kinase M2 (PKM2) is upregulated in
most cancer cells and it is increasingly recognized as a potential therapeutic target in …

Carbonic anhydrases (CAs) play a significant function in diverse pathological and
physiological processes. Their inhibitors and activators are suitable molecules to use as a …

In this study, the activation of pyruvate kinase enzyme in vitro via different urea substituents
in the para position as functional groups of 1, 4-dihydropyridine derivatives synthesized by …

The imbalance between glucose metabolism and cancer cell growth in tumor
microenvironment (TME), which are closely related with the occurrence and progression of …

Introduction: It is well known that cancer cells have an altered metabolism both to meet the
energy needs and to provide initial molecules for the synthesis of macromolecules. To cope …

Metabolic dysfunction-associated fatty liver disease (MAFLD) presents a significant global
health challenge, characterized by the accumulation of liver fat and impacting a …