At least 25 bioactive glass (BG) medical devices have been approved for clinical use by
global regulatory agencies. Diverse applications include monolithic implants, bone void …

Historically, iliac crest bone autograft has been considered the gold standard bone graft
substitute for spinal fusion. However, the significant morbidity associated with harvesting …

OBJECTIVE Spinal fusions are among the most common and effective spinal surgical
practices; however, the current model presents some cost and safety concerns within the …

There is an ongoing debate about the value of animal experiments to inform medical
practice, yet there are limited data on how well therapies developed in animal studies …

OBJECTIVE Infuse bone graft is a widely used osteoinductive adjuvant; however, the simple
collagen sponge scaffold used in the implant has minimal inherent osteoinductive properties …

This chapter deals with the tissue engineering aspects of the mesenchymal tissues—
cartilage and bone. It includes a brief description of the tissue types and their embryonal …

Pseudarthrosis continues to affect a nontrivial proportion of spine fusion patients. Given its
ties to poorer patient outcomes and high reoperation rates, there remains great interest in …

Pediatric spinal fusions have been associated with nonunion rates of approximately 25%,
putting patients at risk for neurological complications while simultaneously incurring …

Despite extensive research, nonunion continues to affect a nontrivial proportion of patients
undergoing spinal fusion. Recently, preclinical studies have suggested that low‐intensity …

Study Design Systematic review Objective Examine the clinical evidence for the use of
osteobiologics in hybrid surgery (combined anterior cervical discectomy and fusion (ACDF) …