Choose Your Own Adventure: A Comprehensive Database of Reactions Catalyzed by Cytochrome P450 BM3 Variants

DJ Fansher, JN Besna, A Fendri, JN Pelletier - ACS catalysis, 2024 - ACS Publications
Cytochrome P450 BM3 monooxygenase is the topic of extensive research as many
researchers have evolved this enzyme to generate a variety of products. However, the …

[HTML][HTML] Current state and future perspectives of cytochrome P450 enzymes for C–H and C= C oxygenation

Y Yan, J Wu, G Hu, C Gao, L Guo, X Chen, L Liu… - Synthetic and Systems …, 2022 - Elsevier
Cytochrome P450 enzymes (CYPs) catalyze a series of C–H and C= C oxygenation
reactions, including hydroxylation, epoxidation, and ketonization. They are attractive …

Peroxide-driven hydroxylation of small alkanes catalyzed by an artificial P450BM3 peroxygenase system

J Chen, F Kong, N Ma, P Zhao, C Liu, X Wang… - ACS …, 2019 - ACS Publications
We report the selective hydroxylation of small alkanes with H2O2 catalyzed by an artificial
P450 peroxygenase system generated from engineered cytochrome P450BM3 variants in …

A unique P450 peroxygenase system facilitated by a dual-functional small molecule: Concept, application, and perspective

S Di, S Fan, F Jiang, Z Cong - Antioxidants, 2022 - mdpi.com
Cytochrome P450 monooxygenases (P450s) are promising versatile oxidative biocatalysts.
However, the practical use of P450s in vitro is limited by their dependence on the co-enzyme …

Triphenyltin degradation and proteomic response by an engineered Escherichia coli expressing cytochrome P450 enzyme

W Yi, K Yang, J Ye, Y Long, J Ke, H Ou - Ecotoxicology and environmental …, 2017 - Elsevier
Although triphenyltin (TPT) degradation pathway has been determined, information about
the enzyme and protein networks involved was severely limited. To this end, a cytochrome …

Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE

BC Tooker, SE Kandel, HM Work, JN Lampe - Journal of Biological …, 2022 - ASBMB
Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen that is highly
prevalent in individuals with cystic fibrosis (CF). A major problem in treating CF patients …

P450 BM3‐Catalyzed Regio‐and Stereoselective Hydroxylation Aiming at the Synthesis of Phthalides and Isocoumarins

C Holec, U Hartrampf, K Neufeld, J Pietruszka - ChemBioChem, 2017 - Wiley Online Library
Cytochrome P450 BM3 monooxygenases are able to catalyze the regio‐and stereoselective
oxygenation of a broad range of substrates, with promising potential for synthetic …

Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

K Frydenvang, MCA Verkade-Vreeker, F Dohmen… - Plos one, 2019 - journals.plos.org
The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …

Normative foundations

KA Zhang - 2022 - ora.ox.ac.uk
This dissertation presents a theory of normativity. The central claim to be advanced is that
human beings are constitutively committed to certain objective moral and other normative …

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L Beckett - 2018 - research-information.bris.ac.uk
Liquid crystal elastomers (LCEs) are polymeric materials capable of rapid, reversible shape
change on application of an external stimulus. However, their application as soft actuators …