Choose Your Own Adventure: A Comprehensive Database of Reactions Catalyzed by Cytochrome P450 BM3 Variants
DJ Fansher, JN Besna, A Fendri, JN Pelletier - ACS catalysis, 2024 - ACS Publications
Cytochrome P450 BM3 monooxygenase is the topic of extensive research as many
researchers have evolved this enzyme to generate a variety of products. However, the …
researchers have evolved this enzyme to generate a variety of products. However, the …
[HTML][HTML] Current state and future perspectives of cytochrome P450 enzymes for C–H and C= C oxygenation
Cytochrome P450 enzymes (CYPs) catalyze a series of C–H and C= C oxygenation
reactions, including hydroxylation, epoxidation, and ketonization. They are attractive …
reactions, including hydroxylation, epoxidation, and ketonization. They are attractive …
Peroxide-driven hydroxylation of small alkanes catalyzed by an artificial P450BM3 peroxygenase system
J Chen, F Kong, N Ma, P Zhao, C Liu, X Wang… - ACS …, 2019 - ACS Publications
We report the selective hydroxylation of small alkanes with H2O2 catalyzed by an artificial
P450 peroxygenase system generated from engineered cytochrome P450BM3 variants in …
P450 peroxygenase system generated from engineered cytochrome P450BM3 variants in …
A unique P450 peroxygenase system facilitated by a dual-functional small molecule: Concept, application, and perspective
S Di, S Fan, F Jiang, Z Cong - Antioxidants, 2022 - mdpi.com
Cytochrome P450 monooxygenases (P450s) are promising versatile oxidative biocatalysts.
However, the practical use of P450s in vitro is limited by their dependence on the co-enzyme …
However, the practical use of P450s in vitro is limited by their dependence on the co-enzyme …
Triphenyltin degradation and proteomic response by an engineered Escherichia coli expressing cytochrome P450 enzyme
Although triphenyltin (TPT) degradation pathway has been determined, information about
the enzyme and protein networks involved was severely limited. To this end, a cytochrome …
the enzyme and protein networks involved was severely limited. To this end, a cytochrome …
Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE
BC Tooker, SE Kandel, HM Work, JN Lampe - Journal of Biological …, 2022 - ASBMB
Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen that is highly
prevalent in individuals with cystic fibrosis (CF). A major problem in treating CF patients …
prevalent in individuals with cystic fibrosis (CF). A major problem in treating CF patients …
P450 BM3‐Catalyzed Regio‐and Stereoselective Hydroxylation Aiming at the Synthesis of Phthalides and Isocoumarins
C Holec, U Hartrampf, K Neufeld, J Pietruszka - ChemBioChem, 2017 - Wiley Online Library
Cytochrome P450 BM3 monooxygenases are able to catalyze the regio‐and stereoselective
oxygenation of a broad range of substrates, with promising potential for synthetic …
oxygenation of a broad range of substrates, with promising potential for synthetic …
Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
K Frydenvang, MCA Verkade-Vreeker, F Dohmen… - Plos one, 2019 - journals.plos.org
The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …
Normative foundations
KA Zhang - 2022 - ora.ox.ac.uk
This dissertation presents a theory of normativity. The central claim to be advanced is that
human beings are constitutively committed to certain objective moral and other normative …
human beings are constitutively committed to certain objective moral and other normative …
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L Beckett - 2018 - research-information.bris.ac.uk
Liquid crystal elastomers (LCEs) are polymeric materials capable of rapid, reversible shape
change on application of an external stimulus. However, their application as soft actuators …
change on application of an external stimulus. However, their application as soft actuators …