Matrikines from basement membrane collagens: a new anti-cancer strategy
JC Monboisse, JB Oudart, L Ramont… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Tumor microenvironment is a complex system composed of a largely altered
extracellular matrix with different cell types that determine angiogenic responses and tumor …
extracellular matrix with different cell types that determine angiogenic responses and tumor …
Computational systems biology approaches to anti-angiogenic cancer therapeutics
Highlights•Systems biology approaches support drug development efforts.•Models of
angiogenesis aid in testing anti-angiogenic therapeutic strategies.•Models provide novel …
angiogenesis aid in testing anti-angiogenic therapeutic strategies.•Models provide novel …
Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation
L Ren, F Han, L Xuan, Y Lv, L Gong, Y Yan… - Free Radical Biology …, 2019 - Elsevier
Clusterin (CLU) is a stress-responding protein associated with cytoprotection in a broad
range of pathological processes. However, clusterin's function in diabetes-induced …
range of pathological processes. However, clusterin's function in diabetes-induced …
Computer-aided design of amino acid-based therapeutics: A review
T Farhadi, SMR Hashemian - Drug design, development and …, 2018 - Taylor & Francis
During the last two decades, the pharmaceutical industry has progressed from detecting
small molecules to designing biologic-based therapeutics. Amino acid-based drugs are a …
small molecules to designing biologic-based therapeutics. Amino acid-based drugs are a …
Peptides as diagnostic, therapeutic, and theranostic tools: Progress and future challenges
Peptides are emerging as a promising candidate for therapeutic as well as diagnostic
applications within the domain of clinical and scientific research. They are recognized for …
applications within the domain of clinical and scientific research. They are recognized for …
Rational, computer-enabled peptide drug design: principles, methods, applications and future directions
DJ Diller, J Swanson, AS Bayden… - Future Medicinal …, 2015 - Taylor & Francis
Peptides provide promising templates for developing drugs to occupy a middle space
between small molecules and antibodies and for targeting 'undruggable'intracellular protein …
between small molecules and antibodies and for targeting 'undruggable'intracellular protein …
Inhibition of breast cancer growth and metastasis by a biomimetic peptide
Metastasis is the main cause of mortality in cancer patients. Though there are many anti-
cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed …
cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed …
Matrikines and the lungs
JK Burgess, M Weckmann - Pharmacology & therapeutics, 2012 - Elsevier
The extracellular matrix is a complex network of fibrous and nonfibrous molecules that not
only provide structure to the lung but also interact with and regulate the behaviour of the …
only provide structure to the lung but also interact with and regulate the behaviour of the …
[HTML][HTML] MiR-23a targets RUNX2 and suppresses ginsenoside Rg1-induced angiogenesis in endothelial cells
XD Wu, T Guo, L Liu, C Wang, K Zhang, HQ Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Rg1 is a predominant protopanaxatriol-type of ginsenoside found in Panax ginseng, and it
has been shown to have anti-cancer effects in multiple types of cancer cells. However, Rg1 …
has been shown to have anti-cancer effects in multiple types of cancer cells. However, Rg1 …
[HTML][HTML] An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy
J Xu, XJ Liu, L Li, SH Zhang, Y Li, RJ Gao, YS Zhen - Oncotarget, 2015 - ncbi.nlm.nih.gov
Recent studies have shown that MMP-14 is highly expressed in a panel of human solid
tumors and poses as a potential molecular target for anticancer drugs. Currently, major …
tumors and poses as a potential molecular target for anticancer drugs. Currently, major …