Arachidonic acid (AA) is the precursor to leukotrienes (LT), potent mediators of the
inflammatory response. In the 35+ years since cysteinyl-LTs were reported to mediate …

Leukotrienes are potent immune-regulating lipid mediators with patho-genic roles in
inflammatory and allergic diseases, particularly asthma. These autacoids also contribute to …

Lysophosphatidylcholine (LPC) is an essential mediator in human lipid metabolism and is
associated with a variety of diseases, but the exact identity of LPC receptors remains …

Determining the three-dimensional structure of proteins in their native functional states has
been a longstanding challenge in structural biology. While integrative structural biology has …

Abstract Leukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory
responses and is a valuable target for anti-inflammation treatment, however, the mechanism …

Abstract Leukotriene B 4 (LTB 4) is generated by the enzymatic oxidation of arachidonic
acid, which is then released from the cell membrane and acts as a potent activator of …

Abstract Leukotriene B 4 (LTB 4) is a lipid mediator rapidly generated from arachidonic acid
in response to various stimuli. This lipid mediator exerts its biological activities by binding to …

Great progress has been made over the past decade in understanding the structural,
functional, and pharmacological diversity of lipid GPCRs. From the first determination of the …

Dihydroxy acid leukotriene (LTB 4) and cysteinyl leukotrienes (LTC 4, LTD 4, and LTE 4) are
inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase pathway …

G protein‐coupled receptors (GPCRs) utilize complex cellular systems to respond to diverse
ligand concentrations. By taking BLT1, a GPCR for leukotriene B4 (LTB4), as a model, our …