Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials
J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …
in recovery. Significant effort has been made to try and minimize neuronal damage following …
On the horizon: cochlear implant technology
JP Roche, MR Hansen - Otolaryngologic Clinics of North America, 2015 - oto.theclinics.com
Most patients with hearing loss significant enough to result in social dysfunction can be
treated with nonsurgical interventions. In many instances, environmental manipulations are …
treated with nonsurgical interventions. In many instances, environmental manipulations are …
Development in the mammalian auditory system depends on transcription factors
KL Elliott, G Pavlínková, VV Chizhikov… - International journal of …, 2021 - mdpi.com
We review the molecular basis of several transcription factors (Eya1, Sox2), including the
three related genes coding basic helix–loop–helix (bHLH; see abbreviations) proteins …
three related genes coding basic helix–loop–helix (bHLH; see abbreviations) proteins …
Toward cochlear therapies
J Wang, JL Puel - Physiological reviews, 2018 - journals.physiology.org
Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …
Age-related hearing loss: sensory and neural etiology and their interdependence
KL Elliott, B Fritzsch, EN Yamoah… - Frontiers in aging …, 2022 - frontiersin.org
Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
Importance of cochlear health for implant function
Amazing progress has been made in providing useful hearing to hearing-impaired
individuals using cochlear implants, but challenges remain. One such challenge is …
individuals using cochlear implants, but challenges remain. One such challenge is …
A novel Atoh1 “self-terminating” mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability
Atonal homolog1 (Atoh1) is a bHLH transcription factor essential for inner ear hair cell
differentiation. Targeted expression of Atoh1 at various stages in development can result in …
differentiation. Targeted expression of Atoh1 at various stages in development can result in …
Neurotrophins and their role in the cochlea
Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by
administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in …
administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in …
Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
Atonal homolog1 (Atoh1, formerly Math1) is a crucial bHLH transcription factor for inner ear
hair cell differentiation. Its absence in embryos results in complete absence of mature hair …
hair cell differentiation. Its absence in embryos results in complete absence of mature hair …
Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear
LA Kilpatrick, Q Li, J Yang, JC Goddard, DM Fekete… - Gene therapy, 2011 - nature.com
Murine models are ideal for studying cochlear gene transfer, as many hearing loss-related
mutations have been discovered and mapped within the mouse genome. However, because …
mutations have been discovered and mapped within the mouse genome. However, because …